Hepatic stimulator substance (HSS) protects liver cells from various toxins by alleviating lesions caused in the mitochondria. This paper demonstrates the necessity of the conserved CXXC catalytic motif (C62-C65) for the mitochondria-targeted anti-apoptotic activity of HSS. Mutating the conserved CXXC motif eliminated the protective effects against H(2)O(2)-induced apoptosis and diminished the ...

We show that observed choices in discounting experiments are consistent with roughly one-half of the subjects using exponential discounting and one-half using quasi-hyperbolic discounting. We characterize the latent data generating process using a mixture model which allows different subjects to behave consistently with each model. Our results have substantive implications for the assumptions m...

The gift-exchange game is a form of sequential prisoner’s dilemma, developed by Fehr, Kirchsteiger, and Riedl (1993), and popularized in a series of papers by Ernst Fehr and co-authors. While the European studies typically feature a high degree of gift exchange, the few U.S. studies provide some conflicting results. We find that the degree of gift exchange is surprisingly sensitive to an appare...

The question of how useful information in financial markets is has been discussed for decades and is still unresolved. In this paper we challenge the widely held belief that success and failure in the stock market can largely be attributed to the information underlying the trading decisions. We present a dynamic multi-period experimental financial market with asymmetrically informed traders who...

Recent bargaining experiments demonstrated an impact of anonymity and incomplete information on subjects’ behavior. This has rekindled the question whether “fair” behavior is inspired by regard for others or is explained by external forces. To test for the importance of external pressure we compare a standard double blind dictator game to a treatment which provides no information about the sour...

Same Process, Different Outcomes: Group Performance in an Acquiring a Company Experiment* It is still an open question when groups perform better than individuals in intellective tasks. We report that in an Acquiring a Company game, what prevailed when there was disagreement among group members was the median proposal and not the best proposal. This aggregation rule explains why groups underper...

We propose a decision making process meant to mimic human behavior. This process is implemented with computational agents. We use this computational testbed to run simulations of two coordination games, the minimum-effort coordination game and the battle of the sexes game. We find that the computational agents exhibit behavior similar to human subjects from previous experimental work. We then u...

We explore the idea that prosocial behavior in laboratory games is driven by social norms imported into the laboratory. Under this view, heterogeneity in behavior across subjects is driven by heterogeneity in sensitivity to social norms. We introduce an incentivized method of eliciting individual norm-sensitivity, and we show how it relates to play in public goods, trust, dictator and ultimatum...

Economics has devoted little attention so far as to whether the type of decision maker matters for economic decisions. However, many important decisions like those on monetary policy or a company’s business strategy are made by (small) groups rather than an individual. We compare behavior of individuals and small groups in an experimental beauty-contest game. Our findings suggest that groups do...

Previous studies have demonstrated that a multitude of options can lead to choice overload, reducing decision quality. Through controlled experiments, we examine sequential choice architectures that enable the choice set to remain large while potentially reducing the effect of choice overload. A specific tournament-style architecture achieves this goal. An alternate architecture in which subjec...