The present series of experiments was undertaken to study the neoplastic potentialities of embryonic tissue, under normal conditions and under influence of carcinogens and other chemicals. This work was the outgrowth of an interest in the problem of the origin of the malignant cell in the adult, and an investigation of the stages in development during which cells may become neoplastic.$ MATERIA...

In this issue of EBioMedicine, Tang et al. describes their results obtumour formation due to mammary gland-specific biallelic Palb2 deletained from analysing the expression of BRCA1 and BECN1 in breast cancer patients from two large datasets (TCGA and METABRIC datasets) (Tang et al., 2015). They found reproducible associations in both datasets of BECN1 expression with oestrogen receptor negativ...

PURPOSE To compare levels of S-glutathiolation and S-cysteinylation occurring at more than 60 cysteine residues of 12 different guinea pig lens water-soluble nuclear crystallins following treatment of the animals with hyperbaric oxygen (HBO). METHODS Guinea pigs (initially 18 months old) were treated 30X (3X per week for 10 weeks) with HBO (2.5 atm 100% O(2) for 2.5 h) as a model to study the...

Background: Due to the incidence and recurrence of bladder cancer (BC), it could be categorized as a clinical and social problem that often occurs at an advanced age. This study was designed to determine the incidence of BC in Isfahan, Iran. Methods: A retrospective descriptive survey of information based on bladder cancer (ICD-O, third edition; C67) was obtained from the Isfahan Deputy of Hea...

habditid nematodes of the Steinernematidae and Heterorhabditidae family are lethal to a broad range of economically important insect pests (Journey and Ostlie, 2000). Entomopathogenic nematodes (EPN) are often applied to sites and ecosystems that routinely receive other inputs that may interact with nematodes, including chemical pesticides, fertilizers, and soil amendments (De Nardo and Grewal,...

Next-to-leading order QCD predictions for 1-jet and 2-jet cross sections in deep inelastic scattering with complete neutral current (γ and Z) and charged current (W) exchange are presented. Electroweak effects in DIS n-jet production are known to become important for Q > ∼ 2500 GeV . These effects can be studied with the fully differential ep → n jets event generator mepjet [1, 2] which allows ...