Allosteric binding pockets in peptide-binding G protein-coupled receptors create opportunities for the development of small molecule drugs with substantial benefits over orthosteric ligands. To gain insights into molecular determinants for this pocket within type 1 and 2 cholecystokinin receptors (CCK1R and CCK2R), we prepared a series of receptor constructs in which six distinct residues in TM...

Dedicated to Professor Heinrich Nöth on the occasion of his 85th birthday Recrystallization of silver pentacyanocyclopentadienide Ag[C5(CN)5] from N,N-dimethylformamide (DMF) gives the polymeric 1 : 1 complex [Ag{C5(CN)5}(DMF)] (1). The Ag+ cation is coordinated by three N atoms of three different [C5(CN)5] anions and two O atoms of two DMF molecules. Each [C5(CN)5] is coordinated via three nei...

The effect of Cu on cobalt/titania nanorod (Co/TNR) catalysts for the promotion carbon monoxide (CO) hydrogenation to hydrocarbons was investigated. Varying amounts (1.5–6.0 wt%) were loaded onto base Co/TNR catalyst using deposition–precipitation method. Characterization by X-ray diffraction (XRD) revealed that particles well dispersed over catalysts. Characterizations temperature-programmed d...

A series of Co/x%Nb2O5/Al2O3 catalysts were prepared by anchoring niobia on an Al2O3 support at different niobia concentrations. Characterization of the structure and nature of surface active sites was attempted in order to correlate the CO hydrogenation activity of these systems with those of the Co/Al2O3 and Co/Nb2O5 catalysts. The effect of the reduction temperature on the CO hydrogenation a...

Complement is implicated in the pathogenesis of rheumatoid arthritis (RA); elevated levels of complement activation products have been measured in plasma, synovial fluid, and synovial tissues of patients. Complement polymorphisms are associated with RA in genome-wide association studies. Coding-region polymorphisms may directly impact protein activity; indeed, we have shown that complement poly...

A graph is C5-saturated if it has no five-cycle as a subgraph, but does contain a C5 after the addition of any new edge. Extending our previous result, we prove that the minimum number of edges in a C5-saturated graph on n vertices is sat(n, C5) = ⌈10(n − 1)/7⌉ − 1 for 11 ≤ n ≤ 14, or n = 16, 18, 20, and is ⌈10(n − 1)/7⌉ for all other n ≥ 5, and we also prove that the only C5-saturated graphs w...

Background and Importance: The development of C5 root palsy is a well-known potential complication of cervical spine surgeries for the correction of cervical spondylotic myelopathy. It typically occurs unilaterally but on extremely rare occasions it might occur as a bilateral anomaly. The value of intraoperative neurophysiologic monitoring in detection of iatrogenic acute versus delayed onset C...

The first recognized human kindred with hereditary deficiency of the fifth component of complement (C5) is described. The proband, a 20-year-old black female with systemic lupus erythematosus since age 11, lacked serum hemolytic complement activity, even during remission. C5 was undetectable in her serum by both immunodiffusion and hemolytic assays. Other complement components were normal durin...

The production of conjugated C4–C5 dienes from biomass can enable the sustainable synthesis many important polymers and liquid fuels. Here, we report first example bimetallic (Nb, Al)-atomically doped mesoporous silica, denoted as AlNb-MCM-41, which affords quantitative conversion 2-methyltetrahydrofuran (2-MTHF) to pentadienes with a high selectivity 91 %. incorporation AlIII NbV sites into fr...

Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and our crystal structure of the C5-SSL7 complex confirms that binding to C5 occurs exclusively through...