We have demonstrated the increased C26:0/C22:0 ratio in the fatty acids of sphingolipid fraction in dried blood spots on filter paper from the patient with adrenoleukodystrophy. The ratio of C26:0/C22:0 in the dried blood spots from the patient was 2.1-fold higher than those of the normal controls. This value was almost the same as the ratio in erythrocyte membrane sphingomyelin from the patien...

In addition to the w-5 olefinic acids found in other Grevillea species, about 10% ?f the acyl groups of G. decOI'a seed oil contain a hydroxy group and an w-5 double bond. Th: chamlengths of these acids are from C22 to C30 , with the largest concentration at the C26 and C28 chamle.ngths. ~le hydroxy group is located on odd carbons from carbon-5 through carbon-l3. These a~lds prevIously .were ~n...

Abstract The graphene-based materials have been used as a potential coating material for nanoparticles due to their excellent passivation. Herein, we report the first time colloidal stability, photothermal profile, thermal cytotoxicity, and photo-cytotoxicity of graphene quantum dots (GQDs) coupled with second infrared window (NIR-II) absorbing gold nanorods (AuNRs/GQDs) compare it oxide (GO)-c...

BACKGROUND: Quercetin is a flavonoid with reported antioxidant, anti-inflammatory and anti-aging effects, may limit muscle wasting in cancer cachexia. OBJECTIVE: To investigate the effect of quercetin on murine C26 cancer-cachexia model assess feasibility non-invasive micro-CT analysis skeletal muscle. MATERIALS AND METHODS: Custom CRM(P) diets supplemented 250 mg/kg (Q) were obtained. Thirty C...

Skeletal muscle tissue is a rare site of tumor metastasis but is the main target of the degenerative processes occurring in cancer-associated cachexia syndrome. Beneficial effects of physical activity in counteracting cancer-related muscle wasting have been described in the last decades. Recently it has been shown that, in tumor xeno-transplanted mouse models, physical activity is able to direc...

Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout mice in order to better understand the function or role of Elovl4. We found th...

A 20-year-old man presented with dizziness and gait disturbance for approximately 2 months. Neurologic examination revealed spontaneous downbeat nystagmus (DBN), limb ataxia, and abnormal tandem gait (video on the Neurology® Web site at Neurology.org). Video-oculography showed augmented DBN during position change (figure 1). MRI revealed diffuse atrophy and signal changes in the brainstem and c...

We describe an HPLC method for measurement of ratios of concentrations of very-long-chain fatty acids (VLCFA) in plasma. The method, which involves ultraviolet detection of p-bromophenacyl derivatives of fatty acids, is validated by comparison with a gas chromatographic-mass spectrometric (GC-MS) method. The correlation between the ratios of 24-carbon fatty acids to 22-carbon fatty acids (C24/C...