BACKGROUND Patients with acquired immunodeficiency syndrome (AIDS)-associated lymphoma/leukemia have a poor prognosis and are frequently treated with low-intensity therapy. The authors investigated the feasibility and efficacy of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD), a dose-intensive chemotherapy regimen, in patients with AIDS-associated B...

background: burkitt lymphoma is a common subtype of non-hodgkin lymphoma in children. it has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. systemic chemotherapy is the mainstay of the treatment for this malignancy in children. in this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (hsc...

Clinical presentation in extranodal and nodal sites of rapidly expanding masses in high-risk populations suggests Burkitt lymphoma (BL). Most patients present with advanced disease because of the rapid rate of tumor growth. BL cells have a remarkably short doubling time. Children in equatorial Africa and Papua New Guinea have endemic BL and present with facial tumors in the jaw or orbit, abdomi...

Burkitt Lymphoma (BL) is a high grade Non-Hodgkins Lymphoma (NHL) that is characterized histopathologically by a mass of diffuse small non-cleaved B cell lymphocytes [1,2]. It is a highly aggressive lymphoma that frequently presents in extranodal sites with a very high proliferation rate. It is the fastest growing tumour, characterized by explosive growth with a doubling time of 24 hours. BL is...

The lymphoma consists of a monomorphic infiltrate of the lymph node by medium-sized cells showing round nuclei with several nucleoli and basophilic cytoplasm. Numerous benign macrophages confer a histologic pattern referred to as “starry sky”. Involvement of the peripheral blood and bone marrow may occur. The related form “Burkitt-like” lymphoma shows intermediate features between diffuse large...

Background Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Accordingly, they were proposed as a new modality in the treatment of Burkitt lymphoma. However, they induce apoptosis with little if any appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can also kill protozoa (such as Trichomo...

This PDF was generated from an article on http://drhoffman.com/ © 2017 Ronald L. Hoffman MD, PC. All Rights Reserved | 1 In the 1960’s, successful British surgeon Denis Burkitt traveled to Uganda to undertake a medical mission among the African native population. There, he characterized a rare form of cancer, eventually to be named “Burkitt’s lymphoma.” But Burkitt is probably best known as the...

RATIONALE Burkitt lymphoma (BL) is an endemic tumor in Africa but rare sporadic cases are diagnosed in Europe. PATIENT CONCERNS A 60-year-old woman was hospitalized with fulminant hematemesis and a history of recurring melena. DIAGNOSES The upper gastrointestinal endoscopy revealed a tumor of the antrum. INTERVENTIONS Emergency gastrectomy was performed. OUTCOMES Gross findings revealed...