نتایج جستجو برای: burkholderia mallei

تعداد نتایج: 5991  

2015
Jonathan David Rachel E. Bell Graeme C. Clark

Members of the Burkholderia species can cause a range of severe, often fatal, respiratory diseases. A variety of in vitro models of infection have been developed in an attempt to elucidate the mechanism by which Burkholderia spp. gain entry to and interact with the body. The majority of studies have tended to focus on the interaction of bacteria with phagocytic cells with a paucity of informati...

Journal: :Infection and immunity 2004
Ricky L Ulrich David Deshazer Harry B Hines Jeffrey A Jeddeloh

Numerous gram-negative bacterial pathogens regulate virulence factor expression by using a cell density mechanism termed quorum sensing (QS). An in silico analysis of the Burkholderia mallei ATCC 23344 genome revealed that it encodes at least two luxI and four luxR homologues. Using mass spectrometry, we showed that wild-type B. mallei produces the signaling molecules N-octanoyl-homoserine lact...

Journal: :Journal of immunology 2010
Andrew Goodyear Abby Jones Ryan Troyer Helle Bielefeldt-Ohmann Steven Dow

Burkholderia mallei is a gram-negative bacterial pathogen of domestic equidae and humans that can cause severe, rapidly life-threatening pneumonic infections. Little is known regarding the role of chemokines and early cellular immune responses in protective immunity to pulmonary infection with B. mallei. Although the role of MCP-1 in gram-positive bacterial infections has been previously invest...

Journal: :Frontiers in Cellular and Infection Microbiology 2013

Journal: :Journal of clinical microbiology 2008
Chayada Sitthidet Joanne M Stevens Narisara Chantratita Bart J Currie Sharon J Peacock Sunee Korbsrisate Mark P Stevens

Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bim...

Journal: :Proceedings of the National Academy of Sciences 2004

Journal: :Clinical and vaccine immunology : CVI 2011
Shimin Zhang Shaw-Huey Feng Bingjie Li Hyung-Yong Kim Joe Rodriguez Shien Tsai Shyh-Ching Lo

Our laboratory has developed more than a hundred mouse monoclonal antibodies (MAbs) against Burkholderia pseudomallei and Burkholderia mallei. These antibodies have been categorized into different groups based on their specificities and the biochemical natures of their target antigens. The current study first examined the bactericidal activities of a number of these MAbs by an in vitro opsonic ...

2017
Vichaya Suttisunhakul Apinya Pumpuang Peeraya Ekchariyawat Vanaporn Wuthiekanun Mindy G Elrod Paul Turner Bart J Currie Rattanaphone Phetsouvanh David A B Dance Direk Limmathurotsakul Sharon J Peacock Narisara Chantratita

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is increasingly used for rapid bacterial identification. Studies of Burkholderia pseudomallei identification have involved small isolate numbers drawn from a restricted geographic region. There is a need to expand the reference database and evaluate B. pseudomallei from a wider geographic distribution th...

2011
Ulrich Wernery Renate Wernery Marina Joseph Fajer Al-Salloom Bobby Johnson Joerg Kinne Shanti Jose Sherry Jose Britta Tappendorf Heidie Hornstra Holger C. Scholz

We confirm a natural infection of dromedaries with glanders. Multilocus variable number tandem repeat analysis of a Burkholderia mallei strain isolated from a diseased dromedary in Bahrain revealed close genetic proximity to strain Dubai 7, which caused an outbreak of glanders in horses in the United Arab Emirates in 2004.

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