Title: Combining information from a clinical data warehouse and a pharmaceutical database to generate a framework to detect comorbidities in electronic health records Authors: Emmanuelle Sylvestre ([email protected]) Guillaume Bouzille ([email protected]) Emmanuel Chazard ([email protected]) Cecil His-Mahier ([email protected]) Christine Ri...

This article summarises the underlying rational and provisions of a report on genetic databases prepared for the European Partnership on Patients’ Rights and Citizens’ Empowerment, a network of the World Health Organisation Regional Office for Europe. The Working Group that prepared the report consisted of Fons Dekkers, Alastair Kent, Graeme Laurie (Convener), and Carmel Shalev. The report is a...

The bacterial photosynthetic reaction center (RC) uses light energy to catalyze the reduction of a bound quinone molecule Q(B) to quinol Q(B)H(2). In RCs from Rhodobacter sphaeroides the protons involved in this process come from the cytoplasm and travel through pathways that involve His-H126 and His-H128 located near the proton entry point. In this study, we measured the pH dependence from 4.5...

High energy irradiation to the hydrogen bonded system is important in relevance with the initial process of DNA and enzyme damages. In the present study, the effects of radiation to catalytic triad have been investigated by means of direct ab-initio molecular dynamics (AIMD) calculation. As a model of the catalytic triad, Ser-His-Glu residue, which is one of the important enzymes in the acylati...