INTRODUCTION Bullous skin diseases, which include, among others pemphigoid, pemphigus, and dermatitis herpetiformis are classified as severe autoimmune dermatoses. It has been shown that a pattern of xenobiotic metabolism may play a role in the pathogenesis of autoimmune diseases. AIM To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous disease...

Background: Immunobullous diseases are morphologically heterogeneous and the differentiation between various subtypes is essential for proper treatment and prognosis. The aim of our study was to analyze and correlate clinical, histopathological, and immunofluorescence findings in autoimmune bullous diseases.Method: A c...

A 13 years old boy with progressive poikiloderma, bullous lesions in the extremities and photosensitivity is reported. Physical examinations were otherwise normal, his physical development was normal, no other family member had a similar disease. Routin laboratory exams were in the normal limits.Histopathology exams from poikilodermatous skin showed atrophy of the epidermis, liquification degen...

Bullous pemphigoid is a distressing disease that causes blisters and itching of the skin. Our study, from England, aimed to find out how many people get bullous for first time each year (incidence), are living with at any given point (prevalence), whether more likely die than similar without (mortality).

Maintenance of an intact epidermis depends on secure adhesion between adjacent keratinocytes and between basal keratinocytes and underlying epidermal basement membrane. The major adhesion units that achieve this are the hemidesmosomes and desmosomes but when these structures are disrupted, for example by gene mutations or autoantibodies, the resilience of the epidermis is lost and blisters deve...

Lichen planus pemphigoides (LPP) is a rare autoimmune blistering disease that is characterized by the development of vesico-bullous skin lesions in patients with lichen planus. The histopathology of LPP reveals a sub_epidermal blister with linear deposition of IgG and /or C3 along the dermal_epidermal junction (DEJ) upon direct immunofluorescence (DIF). We hereunder describe a case of lichen pl...

Autoimmune bullous diseases result from an immune response to molecular components of the desmosome or basement membrane. Bullous diseases are associated with a high degree of morbidity and occasional mortality. Therapy of bullous diseases consists of suppressing the immune system, controlling inflammation and improving healing of erosions. The therapeutic agents used in the treatment of bullou...

Parpose: Direct immunofluorescence (DIF) study on the conjunctiva is currently the classical diagnostic tool used fo the. diagnosis of autoimmune cicatrizing conjunctivitis, which is characterized by the deposition of immunoglobuliis and/or compleme:nt along the conjunctival basement membrane zone (BMZ). To diagnose the type of autoimmune conjunctivitis, we performed d&t immunoeleclron microsco...