A utoimmune diseases probably have a multitude of causes. It is obvious that exogenous agents, particularly drugs, may trigger the development of autoimmune responses leading to bullous eruptions. In the literature several cases of drug-induced (disseminated) bullous pemphigoid (BP) have been reported (see article by Fellner in this issue); however, localized variants of pemphigoid and acquired...

Anti-p200 pemphigoid, also called anti-laminin-γ1 pemphigoid, is a recently defined entity. First reported in 1996, the incidence is relatively rare, with approximately 70 reports in the literature. Clinical presentation is heterogeneous, but the disease most commonly mimics bullous pemphigoid with urticarial papules, plaques, or tense bullae on the trunk or extremities. Described here is a cas...

www.thelancet.com Published online March 6, 2017 http://dx.doi.org/10.1016/S0140-6736(17)30549-4 1 Bullous pemphigoid is the most common autoimmune blistering skin disease, and incidence is on the rise, due at least in part to its association with older age. Treatment of bullous pemphigoid presents a challenge to the clinician, as first-line treatment regimens—either oral corticosteroids or who...

Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND ...

BP: bullous pemphigoid TNF: tumor necrosis factor INTRODUCTION Bullous pemphigoid (BP) is an uncommon skin condition in which erythematous, urticarial papules and plaques progress to form tense bullae, typically in elderly men and women. In this disease, IgG autoantibodies are directed against hemidesmosome proteins, resulting in the formation of subepidermal vesicles. At least 50 drugs have be...

A 78-year-old man presented with cutaneous blisters of the limbs and abdominal distension. He had been treated for various diseases, including liver cirrhosis. He had begun receiving sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, for diabetes mellitus three years before the hospitalization. A skin biopsy demonstrated bullous pemphigoid. Ultrasonography (US) revealed multiple liver tum...