Many genes from retinoid metabolism cause retinitis pigmentosa. Peropsin, an opsin-like protein with unknown function, is specifically expressed in apical retinal pigment epithelium microvilli. Since rhodopsin and RGR, another opsin-like protein, cause retinitis pigmentosa, we used D-HPLC to screen for the peropsin gene RRH in 331 patients (288 with retinitis pigmentosa and 82 with other retina...

BACKGROUND Fragile Histidine Triad protein (FHIT), as a known tumor suppressor protein, has been proposed to play crucial role in inhibiting p53 degradation by MDM2. Studies have confirmed FHIT interaction with p53 or MDM2, although functional interacting domains of FHIT with MDM2 and/or p53 are not completely defined. Thus, through determining the significant structural interacting domains of ...

The viability of a hybrid between male Schistosoma haematobium (Dar es Salaam, Tanzania) and female S. intercalatum (Edea, Cameroun) was studied for up to the F7 hybrid generation and the biological characteristics of the hybrid were compared with those of each of the parental species. Using the total cercarial production/100 exposed snails/5 weeks value (TCP) as an index the hybrid miracidial ...

As has been known, the Nyquist first condition promises no intersymbol interference (ISI) as derived in frequency domain. However, practical implementation using FIR filter truncates Fourier transform by its window and prevents mathematical calculation from reaching ideal solution at zero-ISI. For obtaining better results, an increase window’s length is required general. To address this problem...

Spin foam models are the path integral counterparts to loop quantized canonical theories. In the last few years several spin foam models of gravity have been proposed, most of which live on finite simplicial lattice spacetime. The lattice truncates the presumably infinite set of gravitational degrees of freedom down to a finite set. Models that can accomodate an infinite set of degrees of freed...

Plastic deformation of crystals proceeds through a sequence of intermittent slip avalanches with scale-free (power-law) size distribution. On macroscopic scales, however, plastic flow is known to be smooth and homogeneous. In the present letter we use a recently proposed continuum model of slip avalanches to systematically investigate the nature of the cut-off which truncates scale-free behavio...

AMPLE clusters and truncates ab initio protein structure predictions, producing search models for molecular replacement. Here, an interesting degree of complementarity is shown between targets solved using the different ab initio modelling programs QUARK and ROSETTA. Search models derived from either program collectively solve almost all of the all-helical targets in the test set. Initial solut...