This introduction consists of five parts. First, the central problem of this dissertation, namely, the difficulties instructional designers experience in ensuring an unequivocal interpretation of their designs by software producers, is introduced by means of an illustrative scenario. Second, this “transition bottleneck” is further explored and, third, possible solutions are proposed, emphasizin...

Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

Noncovalent supramolecular assemblies possess in general several unique subunit-subunit interfaces.The basic building block of such an assembly consists of several subunits and contains all unique interfaces. Atomic-resolution structures of monomeric subunits are typically accessed by crystallography or solution NMR and fitted into electron microscopy density maps. However, the structure of the...

Infrastructure as a Service (IaaS) provides a developer the ability to construct applications that dynamically acquire and release potentially large numbers of raw virtual or physical machines (nodes). The Elastic Building Block Runtime (EbbRT) is a new runtime for constructing and retro-fitting applications to take advantage of this opportunity. EbbRT is a realization of the MultiLibOS model[?...

The Layered Coding Transport (LCT) Building Block provides transport level support for reliable content delivery and stream delivery protocols. LCT is specifically designed to support protocols using IP multicast, but it also provides support to protocols that use unicast. LCT is compatible with congestion control that provides multiple rate delivery to receivers and is also compatible with cod...

Symbolic regression that aims to detect underlying data-driven model, has become increasingly important for industrial data analysis when the experimental model structure is unknown or wrong, or the concerned system has changed. For most of the existing algorithms for symbolic regression, such as genetic programming, the convergence speed might be too slow for large scale problems with a large ...

BACKGROUND To explore the feasibility of a new method of achieving a permanent A-V block animal model. METHODS 16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the site of the left ventricular superior-septum, under the a...

This work proposes an algorithm to speed-up convergence of genetic algorithms that is based on the investigation of neighbouring gene values of the successful individuals of the chromosome pool. By performing some statistical inference on neighbour gene values , coherent behaving genes are detected. It is claimed that those coherent acting genes are belonging to the same building block that lea...

A coplanar refractive-diffractive doublet array employing surface-relief diffractive phase elements embedded within poly(methyl methacrylate) microlenses is introduced as an optomechanical building block for optoelectronic integrated systems. The design method, fabrication technology, and results are described. Coplanarity of the quadratic- and linear-phase elements constituting the doublet can...

The antibiotic moenomycin(Flavomycin®)1'2'3) isolated from Streptomyces bambergiensis and other strains is a surface-active phosphorus-containing glycolipid that contains an UV-chromophore, 2-amino-cyclopentane-dione-l,34), a lipid portion, moeno cinol5) a carbohydrate moiety6) consisting of several sugars (D-glucose, D-glucosamine, D-quinovosamine), and phosphorus linked in ester form. The pre...