The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded delivery systems that maintain stability and potency for long times under ambient conditions. In the present study, we seek to better understand the stability and effect of storage conditions on lipidoid nanoparticles (LNPs), which have been previously shown by our group and others to potently deliver RNA...

Join is an operation that is frequently used and the most expensive in processing database queries. In this paper we propose a new efficient join algorithm(called the MLGFJoin) for relations indexed by the tnul~ilevrl grirlfile(MLGF), a multidimensional dynamic hashed file organization. The MLGF-Join uses the domain space partition maintained in the directory of the MLGF. The MLGF-Join can proc...

The recent research in Body Area Networks (BANs) is focused on making its communication more reliable, energy efficient, secure, and to better utilize system resources. In this paper we propose a novel BAN architecture for indoor hospital environments, and a new mechanism of peer discovery with routing table construction that helps to reduce network traffic load, energy consumption, and improve...

Nodes in Mobile Opportunistic Network (MON) have to cache packets to deal with the intermittent connection. The buffer management strategy obviously impacts the performance of MON, and it attracts more attention recently. Due to the limited storage capacity of nodes, traditional buffer management strategies just drop messages based on the property of message, and they neglect the collaboration ...

This letter introduces a buffer management issue in designing SSDs for log-structured file systems (LFSs). We implemented a novel trace-driven SSD simulator in SystemC language, and simulated several SSD architectures with the NILFS2 trace. From the results, we give two major considerations related to the buffer management as follows. (1) The write buffer is used as a buffer not a cache, since ...

It is true that some conventional algorithms do not fit in Continuous Media (CM) environments because of their different properties. A typical example is the buffer replacement algorithmssuch as least recently used (LRU) and most recently used (MRU) strategies. These replacement policies are based on the referencing history for replacing buffered page with lower priority because it is not alway...

We consider a FIFO buffer with finite storage space. An arbitrary input stream of packets arrives at the buffer, but the output stream rate is bounded, so overflows may occur. We assume that each packet has value which is either 1 or a, for some a > 1. The buffer management task is to decide which packets to drop so as to minimize the total value of lost packets, subject to the buffer space bou...

We consider a FIFO buffer with finite storage space. An arbitrary input stream of packets arrives at the buffer, but the output stream rate is bounded, so overflows may occur. We assume that each packet has value which is either 1 or a, for some a > 1. The buffer management task is to decide which packets to drop so as to minimize the total value of lost packets, subject to the buffer space bou...

Buffer Management is central to database systems; it minimizes the access gap between memory and disk. Primary criterion of most buffer management strategies is hitrate maximization (based on recency, frequency). New storage technologies exhibit characteristics such as read/write asymmetry and low read latency. These have significant impact on the buffer manager: due to asymmetry the cost of pa...