The current study aimed to understand the developmental mechanisms regulating bud tip progenitor cells in the human fetal lung, which are present during branching morphogenesis, and to use this information to induce a bud tip progenitor-like population from human pluripotent stem cells (hPSCs) in vitro. We identified cues that maintained isolated human fetal lung epithelial bud tip progenitor c...

The airway retention of inhaled glucocorticosteroids (GCs) depends largely on their lipophilicity. Inhaled budesonide (BUD) becomes highly lipophilic reversibly by the formation of esters, acting as a reservoir of active BUD. Ciclesonide (CIC) was also reported to form esters after hydrolysis to active metabolite (CIC-AM). We have investigated lipophilicity and airway retention of BUD, CIC/CIC-...

Background: Low density lipoprotein (LDL) of egg yolk has been successfully used for stallion and bull semen cryopreservation. However, there is limited information to clarify the effect of LDL or lyophilized LDL on ram semen quality. On the other hand, during semen collection, dilution and cryopreservation we need to protect the spermatozoa from lipid peroxidation. Clove bud has polyphenolic c...

The role of the pectoral fin bud for outgrowth by fin axons was assessed by ablation of pectoral fin buds and by transplantation of fin buds to ectopic sites in the embryos of the Japanese medaka fish (Oryzias latipes). Normally nerves from segments 1-4 (S1-4) and less frequently the S5 nerve converged at the base of the fin bud by extending toward the fin bud on the ventral surface of the axia...

Background Bud development is an adaptation that temperate forest trees have acquired to survive inclement winter conditions and resume growth the following spring. Bud development is a complex physiological and developmental process comprising bud formation, cold and desiccation tolerance development, and dormancy acquisition [1]. Because bud formation is accompanied by growth cessation, the t...

The airway retention of inhaled glucocorticosteroids (GCs) depends largely on their lipophilicity. Inhaled budesonide (BUD) becomes highly lipophilic reversibly by the formation of esters, acting as a reservoir of active BUD. Ciclesonide (CIC) was also reported to form esters after hydrolysis to active metabolite (CIC-AM). We have investigated lipophilicity and airway retention of BUD, CIC/CIC-...

objective: to compare outcome of patients with burns covering less than 15% of total body surface area(tbsa) undergoing early excision and grafting or delayed skin grafting. method : this was a non-randomized clinical trial including 54 patients with less than 15% tbsa burn referring to ghotboddin hospital of shiraz. they were assigned to two study groups, each group including 27 patients: the ...

in order to study the effect of rootstock, scion and some methods of grafting and budding to achieve the best methods of grafting in pomegranate, split factorial experiment was conducted in a completely randomized design in march 2013 in greenhouse at the agricultural college of vali-e-asr university of rafsanjan. factors included rootstock, scion, and methods of grafting and time of grafting. ...