Adoptive T cell transfer, involving the ex vivo expansion of T lymphocytes, is a viable therapeutic approach for both infectious diseases and cancer, with demonstrated efficacy in treating melanoma, Epstein-Barr virus, and HIV-related infections. However, T cell transfer by clonal expansion is not clinically feasible as it does not consistently generate therapeutic quantities of T cells. Effort...

This article reports an all-atom molecular dynamics simulation to study a model pulmonary surfactant film interacting with a carbonaceous nanoparticle. The pulmonary surfactant is modeled as a dipalmitoylphosphatidylcholine monolayer with a peptide consisting of the first 25 residues from surfactant protein B. The nanoparticle model with a chemical formula C188H53 was generated using a computat...

Adoptive T cell transfer, involving the ex vivo expansion of T lymphocytes, is a viable therapeutic approach for both infectious diseases and cancer, with demonstrated efficacy in treating melanoma, Epstein-Barr virus, and HIV-related infections. However, T cell transfer by clonal expansion is not clinically feasible as it does not consistently generate therapeutic quantities of T cells. Effort...

We have studied the stress wave propagation in one-dimensional (1-D) nanoscopic buckyball (C60) system by molecular dynamics (MD) simulation and quantitative modeling. Simulation results have shown that solitary waves are generated and propagating in the buckyball system through impacting one buckyball at one end of the buckyball chain. We have found the solitary wave behaviors are closely depe...

Adoptive T cell transfer, involving the ex vivo expansion of T lymphocytes, is a viable therapeutic approach for both infectious diseases and cancer, with demonstrated efficacy in treating melanoma, Epstein-Barr virus, and HIV-related infections. However, T cell transfer by clonal expansion is not clinically feasible as it does not consistently generate therapeutic quantities of T cells. Effort...

Nanoelectronic devices: nanoparticles or fibers can be integrated into smart devices and has broad applications in variety of fields, such as computer chips, nano-sensor, electrical switching, emission amplification, and more efficient solar cells. Carbon-based nanomaterials are intentionally produced fullerenes, which involve carbon nanotubes and buckyballs (National Geographic 2014). For carb...

The development of innovative carbon-based materials can be greatly facilitated by molecular modeling techniques. Although the Reax Force Field (ReaxFF) can be used to simulate the chemical behavior of carbon-based systems, the simulation settings required for accurate predictions have not been fully explored. Using the ReaxFF, molecular dynamics (MD) simulations are used to simulate the chemic...

We explore the possibility that novel geometrical structures analogous to carbon Fullerenes may exist in Nature on the femtometer scale. The theory of strong interactions , Quantum Chromo Dynamics (QCD) predicts the existence of special topological gluon field configurations called baryon junctions and anti-junctions. Here we show that femto-scale structures, networks or closed (gluon field) ca...

Molecular self-assembly is a promising approach to the preparation of nanostructures. DNA, in particular, shows great potential to be a superb molecular system. Synthetic DNA molecules have been programmed to assemble into a wide range of nanostructures. It is generally believed that rigidities of DNA nanomotifs (tiles) are essential for programmable self-assembly of well defined nanostructures...