A buccal film of buprenorphine (BBUP) was evaluated for safety and efficacy in a multicenter, double-blind, placebo-controlled, enriched-enrollment, randomized-withdrawal study in opioid-experienced patients (30 to ≤160 mg/d morphine sulfate equivalent) with moderate to severe chronic low back pain taking around-the-clock opioid analgesics. Patients' opioid doses were tapered to ≤30 mg morphine...

giant cell fibroma (gcf) was described as a new entity of fibrous hyperplastic soft tissue. it seems that stimulus from an unexplained origin can have a role in its etiology. histopathologically gcf is consisted of multinucleated fibroblasts that have oval shape nuclei within the eosinophilic cytoplasm. surgical excision is the treatment of choice and recurrence is very rare. here we report a c...

AIM The objective of this study was to compare the film thickness of a light body polyvinylsiloxane addition silicone impression material using the "replica technique" (RT) to the film thickness resulting from the cementation of Procera copings. METHODS AND MATERIALS Twenty Procera copings were fabricated on ten casts each having one central incisor and one premolar. The thickness of the ligh...

The preparation of thin composite layers has promising advantages in a variety of applications like transdermal, buccal, or sublingual patches. Within this model study the impact of the matrix material on the film forming properties of ibuprofen-matrix composite films is investigated. As matrix materials polystyrene, methyl cellulose, or hydroxyl-ethyl cellulose were used. The film properties w...