gene, however, progression-free survival was nearly doubled in the cetuximab/BSC group at 3.8 months, compared with 1.8 months in the BSC-alone group (P < 0.0001). For the primary endpoint of overall survival, again among patients with mutated K-ras genes, findings were similar: 4.5 months for cetuximab plus BSC and 4.6 months for BSC alone (P = 0.89). For wild-type K-ras, there was a significa...

INTRODUCTION Sunitinib is a multiselective oral inhibitor of several tyrosine-kinase receptors that has demonstrated its efficacy in patients with metastatic and/or unresectable gastrointestinal stroma tumours (GIST) who were resistant to or intolerant to previous treatment with imatinib. The purpose of this study is to assess the cost-effectiveness of sunitinib vs. best supportive care (BSC) i...

In this article, we focus on the Balanced Scorecard (BSC) as a discursive practice. Instead of asking whether the figures in the BSC correspond to reality, or whether they serve the users’ purposes and behave according to their intentions, we have chosen to analyse how the BSC partakes in shaping the world it is intended to reflect. Two case studies will be presented in order to demonstrate how...

We consider Bott-Samelson varieties BSc(s) for a semisimple compact Lie group C corresponding to sequences of (not necessarily simple) reflections s. Let n be the length s, K maximal torus in and W Weyl C. For any set R not overlapping integer pairs (i,j) such that 1?i?j?n function v:R?W, we subspace BSc(s,v)?BSc(s) solutions equations C/K requiring K-orbit product coordinates counted from i j ...

The objective of this article is to develop a Balanced Scorecard (BSC) for Sustainable Supply Chain Management (SSCM). The BSC provides a framework for simulation experiments which serve to evaluate benefits of sustainability investments for the partners within a recycling supply chain. A system dynamics approach was employed to perform the simulation experiments. First, the simulations help to...

Inter-Rater Reliability and Downstream Financial Implications of Electrocardiography Screening in Young Athletes Harshil Dhutia, BSc, MRCP; Aneil Malhotra, BSc, MRCP, PhD; Tee Joo Yeo, MRCP; Irina Chis Ster, MSc, PhD; Vincent Gabus, MD; Alexandros Steriotis, MD; Helder Dores, MD; Greg Mellor, MB BChir, MRCP; Carmen García-Corrales, MD; Bode Ensam, MRCP; Viknesh Jayalapan, MRCP; Vivienne Anne Ez...

 T. O. White, FRCSEd(Tr&Orth), MD, FFTEd, Consultant Orthopaedic Trauma Surgeon  S. P. Mackenzie, MBChB, BSc MedSci (Hons), MRCS, Specialty Registrar  T. H. Carter, BSc(Hons), MBChB, MRCS(Ed), Specialty Registrar  O. R. Prescott, BSC BMBS PGCert, Foundation Doctor  A. D. Duckworth, BSc(Hons), MBChB, MSc, FRCSEd(Tr&Orth), PhD, Specialty Registrar  J. F. Keating, MPhil, FRCSEd(Tr&Orth), Con...

The intestinal nematode Baylisascaris schroederi is an important cause of death for wild and captive giant pandas. Inorganic pyrophosphatases (PPases) are critical for development and molting in nematode parasites and represent potential targets for vaccination. Here, a new PPase homologue, Bsc-PYP-1, from B. schroederi was identified and characterized, and its potential as a vaccine candidate ...

Background The global increase in acceptance and use of herbal remedies in recent times is still accompanied with poor knowledge of their potential adverse effects and the toxicological implications of their use are underestimated. Methods Bon-santé Cleanser® (BSC), a polyherbal containing Anogeissus leiocarpus, Terminalia ivorensis, Massularia acuminate and Macuna pruriens, is an "energizer ...

We introduce a community detection algorithm (Fluid Communities) based on the idea of fluids interacting in an environment, expanding and contracting as a result of that interaction. Fluid Communities is based on the propagation methodology, which represents the state-of-the-art in terms of computational cost and scalability. While being highly efficient, Fluid Communities is able to find commu...