A t present, human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition. The clinical concept of BAC needs to be re-evaluated with careful attention to the 2004 World Health Organization (WHO) criteria [1] due to major clinical implications. Series published in the literature before 2000, i.e. before the WHO definition of BAC, had not discerned a specific survival advanta...

many different radiologic appearances. The common radiologic appearances are those of a solitary peripheral pulmonary nodule, multiple nodules and lobar or diffuse consolidation (1). The unusual radiologic appearances include diffuse disease with minimal or no radiologic signs, expansive pulmonary consolidation without air bronchograms, lobar atelectasis and cavitation (1). To the best of our k...

Two adults, both non-smokers, with large peripheral lung cysts, which were of long standing (12 and nine years), were found to have well differentiated mucus secreting adenocarcinomas with a bronchioloalveolar growth pattern associated with the cysts. Lobectomy is likely to have been curative in one of the cases and earlier surgery might have been so in the other. The fact that many of the repo...

A 78-year-old womanwas found to have a small bronchioloalveolar carcinoma with ground-glass attenuation in the gravity-dependent gradient in the left lower lobe during a preoperative chest computed tomography (CT) evaluation, which was performed for previously-diagnosed adenocarcinoma of the right upper lobe. To remove the gravitational effect of the CT, the patient underwent a thin section CT ...

The tumor-to-tumor metastasis is a rare event. The lung tumors are the most common donor tumors in tumor-to-tumor metastasis, but are exceedingly rare as a recipient. Here, we report a case of papillary thyroid carcinoma (PTC) metastasizing to adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma) of the lung in a 44-year-old woman who underwent total thyroidectomy for PTC 8 years ...

The candidate tumor-suppressor gene hyaluronidase 2 (HYAL2) encodes a glycosylphosphatidylinositol-anchored cell-surface protein that serves as an entry receptor for jaagsiekte sheep retrovirus, a virus that causes contagious lung cancer in sheep that is morphologically similar to human bronchioloalveolar carcinoma. The viral envelope (Env) protein alone can transform cultured cells, and we hyp...