Background: Tumor thickness is of great importance in the management of cutaneous malignant melanoma (MM): this variable not only affects prognosis but is also a key factor in planning surgical margins and selecting candidates for sentinel node biopsy. Breslow depth is the standard histologic measure of thickness, but technological advances have provided imaging techniques such as cutaneous ult...

BACKGROUND Tumor thickness is of great importance in the management of cutaneous malignant melanoma (MM): this variable not only affects prognosis but is also a key factor in planning surgical margins and selecting candidates for sentinel node biopsy. Breslow depth is the standard histologic measure of thickness, but technological advances have provided imaging techniques such as cutaneous ultr...

BACKGROUND Cutaneous melanoma (CM) is considered serious for causing frequent metastasis, presenting high mortality, resistance to available therapies and incidences in laboring activity. OBJECTIVES To study the histopathological types of cutaneous melanoma in Palmas-TO from 2001 to 2011, according to risk factors, location of lesions, Clark levels and Breslow thickness. METHODS A descripti...

Let be a random sample from a normal distribution with unknown mean and known variance The usual estimator of the mean, i.e., sample mean is the maximum likelihood estimator which under squared error loss function is minimax and admissible estimator. In many practical situations, is known in advance to lie in an interval, say for some In this case, the maximum likelihood estimator...

Salah satu hal penting dalam analisis statistik adalah prosedur estimasi suatu fungsi padat peluang yang biasa disebut densitas. Ada dua metode pendekatan biasanya digunakan, yaitu parameter terkait dengan asumsi distribusi tertentu dan densitas secara non parametrik. Metode parametrik sering kita jumpai histogram.
 Beberapa kelemahan histogram menjadi acuan untuk dikembangkannya lain kern...

Abstract Maternal lactational investment can affect female reproductive rates and offspring survival in mammals be biased towards infants of one sex. We compared estimates lactation effort among mothers, assessed as their potential milk contribution to age-specific infant diets (mother-infant differences fecal stable nitrogen isotopes, δ 15 N), the timing weaning (infant age at last nursing bou...

Background. Sentinel lymph node biopsy (SLNB) is a standard procedure for patients with localized cutaneous melanoma. The National Comprehensive Cancer Network (NCCN) Melanoma Panel has reinforced the status of the sentinel lymph node (SLN) as an important prognostic factor for melanoma survival. We sought to identify predictive factors associated with a positive SLNB and overall survival in ou...

INTRODUCTION The objective of this study is to analyze our experience in the use of sentinel node biopsy (SNB) in melanoma and identify the predictive factors of positive SNB and multiple drainage. MATERIAL AND METHODS Retrospective study of patients who underwent SNB for melanoma between August of 2000 and February of 2013. RESULTS SNB was performed in 125 patients with a median of age of ...

OBJECTIVE To assess data on survival, recurrence and histological factors in positive and negative sentinel lymph nodes in thin melanoma cases. METHODS A systematic review was conducted on observational studies in four databases (Cochrane Library, Medline, Embase and Lilacs). Positive and negative micrometastases in sentinel lymph node biopsy were compared regarding the clinical outcomes - de...