background in patients with chronic hepatitis c, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. objectives in turkey, telaprevir has been used since march 2013. we aimed to evaluate resul...

conclusions in conclusion, chit1 24 bp duplication might not be a candidate gene for susceptibility to ptb. larger studies are necessary to confirm these findings in various populations. results homozygous wild type, heterozygous and homozygous mutant frequencies of chit1 24 bp duplication polymorphism were 43.9%, 43.9% and 12.2% in controls and 42.8%, 45.1% and 12.1% in ptb patients. we found ...

background: hepatitis c virus (hcv) is one of the main causative factors of liver disease which can lead to chronic hepatitis c infection in 80% of cases. hcv genotypes have a special worldwide geographic distribution. the goal of the present study was to detect hcv genotypes in patients with anti-hcv positive titers in golestan province, iran. materials and methods: in this cross-sectional stu...

background and objectives: dengue has re-emerged as an important arboviral disease causing significant morbidity. it has become hyperendemic in the indian subcontinent with all four known dengue serotypes circulating. materials and methods: multiple sequence alignments and phylogenetic trees of denv-3 were constructed to determine the extent of the isolated dengue virus genetic heterogeneity an...

background: successful treatment to eliminate hcv rna depends on the identified genotype. in the present study, we com­pared the frequency of different hcv genotypes, during four years study (2004 till 2008).  methods: sera specimens were received from 16 provinces of iran. we used high pure viral nucleic acid purification kit for extraction and samples were tested with improved form of rt-pcr ...

background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...

background: endometriosis is one of the most common gynecologic disorders. it is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. there is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. glutathione-s-transferase m1 (gstm1) is one of the genes involved in detoxification of endogenous ...

the patient was infected with hcv subtype 6a. prior to this case, there have been no previous reports on the isolation of this genotype/subtype from any other iranian patient. previous epidemiological studies provide valuable information about the distribution patterns of different hcv genotypes. however, infection with genotypes other than common ones should be flagged by specialists and diagn...

(Triticum aestivum) is staple food for more than half of the world population. In present study 10 genotypes were sown to check wheat genotype's genetic variability and under late sowing. Exploration occurred at Department Agriculture, BZU, Bahadur sub-Campus, Layyah during 2019-2020. The investigation was spread out in understanding Randomized Complete Block Design (RCBD). Perceptions on vario...

background and aims: hdv is a defective satellite virus and classified in genus deltavirus. its disease is related and limited to hbv-infected patients. acute infection of delta agent occurs in two different patterns simultaneous infection with both hbv & hdv or super infection of chronically hbv infected patients that lead to more sever type of hepatitis. according to genetic diversity of geno...