traumatic brain injury (tbi) initiates a cascade of numerous pathophysiological events that evolve over time. despite the complexity of tbi, research aimed at therapy development has almost exclusively focused on single therapies, all of which have failed in multicenter clinical trials. a variety of brain insults, including traumatic brain injury, encephalitis, stroke, and status epilepticus (s...

traumatic brain injury (tbi) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. the use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of tbi. in the present study, we surveyed the beneficial effec...

abstract introduction: there is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. insulin receptors hybridize with insulin like growth factor receptor (igf-i) to transduce the signals in different areas of the brain. in this article we aimed at investigating whether the expression of igf-i receptor and igf-i binding proteins (igfbp1) is changed...

background & importance: our study was performed based on the first case, reported in english, of a patient with three contemporary lesions, an extra-axial malformation and two vascular ones. case presentation: a 62-year-old man referred to our clinic due to right hand tremor associated to a slowing of idea-forming function and movements. the neuroradiological evidence showed a right fronto-tem...

background: palliative whole brain radiotherapy (wbrt) has been the standard treatment for brain metastases. ionizing radiation is known to be one of the most potent cataractogenic agents. we aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (oar) in patients with brain metastasis who undergone wbrt. materials and methods: ten conse...

traumatic brain injury (tbi) is one the most common cause of disability between young adults. these people have been socially isolated during post-surgery traumatic brain injury. in this study we investigated the effect of social isolation on the structural deficits after tbi in the young rats. young rats were divided into control group with social interaction, sham group with social isolation ...

traumatic brain injury (tbi) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. in vitro models of tbi can help us to describe the pathobiological mechanisms. in vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. other advantages of in vitro mo...

Background: Organotypic Hippocampal Brain Slices (OHBS) provide a better alternative to in vivo models to scrutinize Traumatic Brain Injury (TBI). We followed a well-established TBI protocol but noticed that several factors might influence the results in such a set-up. Here, we describe a structured approach to generate more comparable results and discuss why specific eligibility criteria shoul...