Sir, It was with great interest that we read the paper from Anderson et al. (2009) in which the authors addressed two competing hypotheses regarding developmental outcome after early versus late brain lesions. The first hypothesis assumes a greater compensatory potential during early brain development, while the second hypothesis proclaims that the young brain may be especially sensitive to ins...

Recent community- and hospital-based studies of epilepsy from its onset suggest a much better prognosis than previously recognized, with about three-quarters of patients entering long-term remission on current medication. The first two years of medication are crucial in determining longer-term prognosis. Early effective therapy may be important in preventing the evolution of chronic epilepsy. A...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...

Segmentations of brain lesions from Magnetic Resonance (MR) images is crucial for quantitative analysis of lesion populations in neuroimaging of neurological disorders. We propose a new method for segmenting lesions in brain MRI by inferring the underlying physical models for pathology. We use the reaction-diffusion model as our physical model, where the diffusion process is guided by real diff...

Two unselected groups of patients, affected by a mono-hemispheric cerebral lesion, were studied in two seperate services by means of various tasks of copying drawings, in order to check the hypothesis of a qualitative difference between unilateral spatial neglect (USN) of right and left brain-damaged patients. In both experimental groups drawing asymmetries were found to be of slight importance...

Traditionally, philosophers have appealed to the phenomenological similarity between visual experience and visual imagery to support the hypothesis that there is significant overlap between the perceptual and imaginative domains. The current evidence, however, is inconclusive: while evidence from transcranial brain stimulation seems to support this conclusion, neurophysiological evidence from b...

The association between disappearing brain lesions, psychosis and epilepsy in two patients is reported for the first time. Mechanisms to explain the underlying pathogenesis are postulated.

Lesion-behaviour mapping aims at predicting individual behavioural deficits, given a certain pattern of brain lesions. It also brings fundamental insights on organization, as lesions can be understood interventions normal function. We focus here the case stroke. The most standard approach to lesion-behaviour is mass-univariate analysis, but it inaccurate due correlations between different regio...