Abbreviations: Ab, amyloid beta; AD, Alzheimer’s disease; BBB, blood–brain barrier; BDNF, brain derived neurotrophic factor; CSF, cerebrospinal fluid; GPX, glutathione peroxidase; GR, glutathione reductase * Corresponding author. Tel.: +2

Background The popular recreational abuse drug 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') produces acute and long-lasting deficits in several markers of the serotonergic (5-HT) system. BDNF (brain derived neurotrophic factor) is a prominent trophic factor of serotonergic fibers. The aim of this study was to characterize the damage of serotonergic fibers in the frontoparietal cortex and...

Gilland, Kaitlyn Elizabeth. M.S., Purdue University, May 2016. Short-Term Effects of a Western Diet on the Number of Brain-Derived Neurotrophic Factor Immunoreactive Neurons in the Hypothalamic Arcuate, Ventromedial and Paraventricular Nuclei. Major Professor: Edward Fox. Brain-derived neurotrophic factor (BDNF) is an important anorexogenic factor and has been shown to be involved in obesity. I...

We previously reported a case in which steroid-induced psychosis was eliminated with risperidone treatment in a patient with polyarteritis nodosa (PN). In the present report, we longitudinally tracked the serum levels of brain-derived neurotrophic factor (BDNF). We found that corticosteroid lowered serum BDNF levels, and improvement of psychiatric symptoms was intact with the serum BDNF levels ...

Brain-Derived Neurotrophic Factor (BDNF) is a neuroprotectant candidate for neurodegenerative diseases. However, there are several clinical concerns about its therapeutic applications. In the current study, we selected BDNF-mimicking small peptides from phage-displayed peptide library as alternative molecules to the clinical challenges. The peptide library was screened against BDNF receptor (Ne...

Purpose We tested the hypothesis that short-term treatment with brain derived neurotrophic factor (BDNF) would alter the contractile characteristics of rabbit extraocular muscle (EOM). Methods One week after injections of BDNF in adult rabbit superior rectus muscles, twitch properties were determined in treated and control muscles in vitro. Muscles were also examined for changes in mean cross...

Background: Some studies highlighted the role of Jujuboside A as a potent antioxidant on ischemic neurons. However, definitive effect this substance change in expression neuroprotective genes has not been clearly identified. Therefore, study aimed to investigate effects proliferation-inducing and cell count enhancement hippocampus after induction transient global ischemia/reperfusion. Materials...

BACKGROUND: Obesity has been widely associated with structural and functional changes in the brain, whereas inflammation is one of potential mechanisms involved these changes.
 OBJECTIVE: This study aims to prove relationship between serum brain-derived neurotrophic factor (BDNF) levels obesity predictor markers (body mass index waist hip ratio) (interleukin-6 Tumor Necrosis Factor-alpha) ...

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neuronal survival molecules which utilize the Trk family of tyrosine kinase receptors. Using double-label in situ hybridization, we demonstrate that mRNAs for BDNF and its high-affinity receptor TrkB are coexpressed in hippocampal and cortical neurons. Also, a large number of neurons in these areas coexpress NGF and BDNF...

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. We have generated bacterial artificial chromosome (BAC) transgenic mice harboring 207 kb of the rat BDNF (rBDNF) locus containing the gene, 13 kb of genomic sequences upstream of BDNF exon I, and 144 kb downst...