objective(s) the brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. the hippocampus is highly vulnerable to ischemic insults, particularly the ca1 pyramidal cell layer. there is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. previous studies reported that pentoxifylline (ptx) has a neuroprote...

A small number of individuals have severe musical problems that have neuro-genetic underpinnings. This musical disorder is termed "congenital amusia," an umbrella term for lifelong musical disabilities that cannot be attributed to deafness, lack of exposure, or brain damage after birth. Amusics seem to lack the ability to detect fine pitch differences in tone sequences. However, differences bet...

Alcohol directly affects astroglial cell function, including inflammation-related activity.  And it also affects microglial cell development and function in specific ways that interfere with microglial interactions with the immune system and with neurons. Neuroinflammatory processes might be involved in alcohol-induced brain damage. Alcohol use, misuse and getting used to it causes differe...

Objective(s) The brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. The hippocampus is highly vulnerable to ischemic insults, particularly the CA1 pyramidal cell layer. There is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. Previous studies reported that pentoxifylline (PTX) has a neuroprot...

Introduction: The role of ovarian hormones and nitric oxide (NO) on oxidative damage in brain tissues as well as learning and memory has been widely investigated.The present study was carried out to evaluate the effect of the precursor of NO, L-Arginine on learning and brain damage due to oxidative stress in ovariectomized (OVX) rats.Methods: Thirty -two rats were divided into four groups: 1) S...

one hundred patients underwent elective cranioplasty for high velocity missile injury of the head during a 30-month-period study and investigation in amiralmomenin hospital affiliated to iran university of medical sciences. deep penetrating wounds were the most frequent injuries seen during this study. three patients presented with massive bone defects and progressive neurological deficit and d...

localization of brain lesions and prevention of damage to vital structures are important in operation of brain pathologies. despite development of many techniques including angiography, mri, sonography, and frame base stereotaxy, a more accurate localizing technique is still needed (1, 2). a step forward to achieve this goal is to develop a navigation system. in this manuscript, we explained so...

Introduction: Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. Propolis has antioxidant properties. The main ch...

Although it is generally assumed that brain damage predominantly affects only the function of the damaged region, here we show that focal damage to critical locations causes disruption of network organization throughout the brain. Using resting state fMRI, we assessed whole-brain network structure in patients with focal brain lesions. Only damage to those brain regions important for communicati...