Three new rimantadine Schiff bases (RSBs) were prepared, and then the interaction of RSBs with bovine serum albumin (BSA) was investigated using fluorescence, synchronous fluorescence, UV-vis absorption spectroscopy under physiological conditions. The results showed that the three RSBs effectively quenched the intrinsic fluorescence of BSA via static quenching. Binding constant (Ka), number of ...

Currently, nanotechnology is considered a promising strategy to enhance drug solubility and other physicochemical properties. Albumin biopolymer that can be used in delivery systems due its biodegradability biocompatibility. The aim of this study was prepare characterize albumin nanoparticles with chlorambucil as controlled system. Different concentrations were incubated bovine serum (BSA) orde...

Previous clinical research has suggested high-affinity binding of flavopiridol (FLAP) to human blood serum proteins, specifically either human serum albumin (HSA) or human alpha-1-acid glycoprotein (hAGP), when compared to fetal bovine serum albumin (BSA) or bovine alpha-1-acid glycoprotein (bAGP) used in pre-clinical assays. This high-affinity binding was suggested as the reason for its poor h...

We report on the production of composite semiconductor CdZnS nanoparticles by adopting an inverse micellar route, using bis (2-ethylhexyl) sulfosuccinate (aerosol-AOT) as surfactant and with a degree of hydration w0 = [H2O] : [AOT] = 8.9. Prior to bioconjugation (conjugation with bovine serum albumin (BSA)), the hydrophobic surface of the nanocrystals were made hydrophilic with thiol treatment ...

Graphene oxide (GO) was found to effectively enhance the selectivity of aggregation-induced emission (AIE) biosensors, and a new method based on GO and AIE molecules was proposed to detect bovine serum albumin (BSA) with high sensitivity and selectivity.

BACKGROUND Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. However, the molecular mechanism by which (20S) G-Rh2 triggers its functions and how target animals avoid its cytotoxic action remains largely unknown. METHODS Phage display was used to screen the human targets of (20S) G-Rh2. Fluorescence spectroscopy and UV-visib...

Backgound/Objectives Urolithins (UROs) are the metabolites derived from gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in intestine, UROs transported through systemic circulation to various tissues where they can express biological function as antimicrobial, anti-inflammatory, anticancer agents. In addition blood plasma, be found glucuronide sulfat...

The surface properties of aqueous dispersions worm-like fibril aggregates bovine serum albumin (BSA) differ from those the adsorption layers native protein. BSA fibrils are characterized by slower changes tension and dynamic elasticity also have different steady-state values properties. fourfold compression layer leads to noticeably higher pressures than a compressed protein, indicating formati...