Alphaherpesvirinae family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter ...

Introduction: Herpes Simplex Virus type 2 (HSV-2)  is a highly prevalent sexually transmitted infection (STI) The prevalence of HSV-2 infection is increasing in many populations and geographic areas . Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes and is almost always sexually transmitted. Most HSV-2 infections are consequently expected to occur after the onset of sexua...

Herpes simplex virus type 1 (HSV-1) with a worldwide distribution has been reported in all human populations, resulting in a clinical spectrum of infections. Although HSV type 2 (HSV-2) is known as the most common cause of genital herpes, an increasing number of cases with genital herpes are caused by HSV-1. The present study aimed to discuss the changes in the epidemiology of HSV-1 infection i...

acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. acyclovir triphosphate inhibits viral dna-polymerase terminating the chain and...

ulcerative colitis (uc) is one type of inflammatory bowel disease (ibd). herpes viruses have been suggested as possible etiological agents of uc and crohn’s disease (cd). the aim of this study was to investigate the prevalence of herpes simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with uc in comparison with healthy subjects by using pcr technique. in this ...

BACKGROUND There are limited data available, in Ireland or elsewhere, to determine the extent of exposure to various endemic diseases among beef cows and factors associated with exposure to causative pathogens. The objectives of this study were to determine the herd and within herd prevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Leptospirosis and Neosporosis in...

Homologous recombination between strains of the same alphaherpesvirus species occurs frequently both in vitro and in vivo. This process has been described between strains of herpes simplex virus type 1, herpes simplex virus type 2, pseudorabies virus, feline herpesvirus 1, varicella-zoster virus, and bovine herpesvirus 1 (BoHV-1). In vivo, the rise of recombinant viruses can be modulated by dif...

Background and Aims: Herpes simplex virus type 1 (HSV-1) belonging to herpes viridae family is a normal human pathogen with benign lesions in immunocompromised patients which creates serious problems. Acyclovir is used to treat herpetic infections. Because of developing drug-resistant strains, the use of medicinal plants and their related compounds with fewer side effects is considered for the ...

brown alga, turbinaria conoides was successively extracted with n-hexane, cyclohexane, methanol and ethanol:water (1:1). the extracts were evaluated for antibacterial and antifungal activities by disc diffusion method. minimal inhibitory concentration was determined for active extracts by broth dilution method. the antiviral activity and cytotoxicity of the extracts were tested in human embryon...

background and objectives: febrile convulsion is a common disorder in children. viral infections such as human herpes virus 6 (hhv-6) which results in roseola infantum may contribute to developing seizure. the objective of this study was to determine the prevalence of hhv-6 by detecting dna in cerebrospinal fluid (csf) of children with febrile convulsion and without any rash of roseola infantum...