PURPOSE Cystoscopic intradetrusor injection of botulinum toxin has helped patients with refractory overactive bladder but with the increased risks of urinary tract infection and urinary retention. We assessed whether catheter instillation of 200 U onabotulinumtoxinA formulated with liposomes is safe and effective for the treatment of overactive bladder. MATERIALS AND METHODS This 2-center, do...

Botulinum neurotoxins (BoNTs) are some of the most poisonous natural toxins. Botulinum neurotoxins associate with neurotoxin-associated proteins (NAPs) forming large complexes that are protected from the harsh environment of the gastrointestinal tract. However, it is still unclear how BoNT complexes as large as 900 kDa traverse the epithelial barrier and what role NAPs play in toxin translocati...

In coronary artery bypass surgery, arterial grafts result in improved patency rates. However, these grafts frequently fail due to spasm. Papaverine has been used to prevent graft spasm, but its effect is short-lived. Botulinum toxin inhibits muscle contraction for about three months. We investigated the usefulness of botulinum toxin in preventing arterial grafts spasm in vitro. Samples of abdom...

Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types. Infant botulism, an intestinal toxemia orphan disease, is the most common form of human botulism in the United States. It results from swallowed spores of...

This article presents a review of current modern research on the use botulinum toxin therapy for prevention and treatment patients with chronic migraine, as well briefly outlines views pathogenesis its impact quality life patients' ability to work. Botulinum A is currently drug first choice migraine. Numerous studies confirm effectiveness safety in clinical practice.

Botulinum toxin is a natural purified protein and one of the strongest biological poisons--neurotoxin. It is produced by the bacterium Clostridium botulinum. Its medical usage started in USA in 1981 and in Europe in 1992. There are seven different immune types of the toxin: A, B, C1, D, E, F and G. Toxin types A and B are used to decrease muscular spasticity. Botulinum toxin prevents the format...

purpose: to report the outcomes of surgical and non-surgical treatment for sixth nerve palsy and paresis in our center. methods: hospital records of 33 patients (35 eyes) with sixth nerve dysfunction who were referred to labbafinejad medical center from september 1996 to september 2006 and underwent surgical procedures or botulinum toxin injection were reviewed. results: patients were divided i...

background: spasticity is one of the problems after a stroke. due to this increase in muscle tone, patients are confronted with problems in motor control and difficulties in activities of daily living and complications such as shortness and contracture. the aim of this study was to examine the effects of the simultaneous use of both splint and botulinum toxin-a (btx-a) injection on spasticity, ...

background: spasticity is one of the problems after a stroke. due to this increase in muscle tone, patients are confronted with problems in motor control and difficulties in activities of daily living and complications such as shortness and contracture. the aim of this study was to examine the effects of the simultaneous use of both splint and botulinum toxin-a (btx-a) injection on spasticity, ...

We have read the case report of Al-Ahmad and Al-Qudah1 regarding the use of botulinum toxin type A in the treatment of masseter hypertrophy, and we agree with the authors when they reported that botulinum toxin type A is an option for patients who declined surgical treatment. However, we would like to make some considerations concerning this type of treatment that can contribute to the authors’...