A large number of molecular, cellular, and epidemiologic factors have been implicated in the regulation of bone development. A major unsolved problem is how to integrate these disparate findings into a concept that explains the development of bone as an organ. Often, events at the organ level are simply presented as the cumulative effect of all factors that individually are known to influence b...

osteosarcoma (os) is the eighth common cancer of childhood and its incidence is 4 cases in one million in children younger than 14. facial os incidence is estimated between 8 and 10% of os cases. the main etiology of os is unknown, but various predisposing factors are proposed such as radiation, radiotherapy, some benign bone diseases like paget’s disease or fibrous dysplasia. there is a 5-year...

Longitudinal growth of long bones takes place at the growth plates. The growth plate produces new bone trabeculae, which are later resorbed or merged into the cortical shell. This process implies transition of trabecular metaphyseal sections into diaphyseal sections. We hypothesize that the development of cortical bone is governed by mechanical stimuli. We also hypothesize that trabecular and c...