Introduction Obsessive-compulsive disorder (OCD) is a heterogeneous and debilitating neuropsychiatric disorder. First-line antidepressants with Selective Serotonin Reuptake Inhibitors (SSRIs) Clomipramine (a tricyclic antidepressant) are unresponsive or partially responsive in 40% of treated patients. Preclinical studies have shown that cannabidiol (CBD) can reduce compulsive behavior animals, ...

Background: Preliminary studies using neuronavigated TBS-50Hz (50Hz pulse frequency theta burst stimulation) and TBS-30Hz have shown promise for the treatment of obsessive-compulsive disorder (OCD), but TBS-20Hz has not been tested OCD or with depression anxiety. Methods: Fourteen patients moderate-to-severe comorbid major depressive (MDD), generalized anxiety (GAD) and/or panic (PD) were treat...

BACKGROUND AND OBJECTIVE Randomized controlled trials (RCTs) on repetitive transcranial magnetic stimulation (rTMS) as augmentation of selective serotonin reuptake inhibitors (SSRIs) for SSRI-resistant obsessive-compulsive disorder (OCD) have yielded conflicting results. Therefore, this meta-analysis was conducted to assess the efficacy of this strategy for SSRI-resistant OCD. METHODS Scienti...

OBJECTIVE To examine the basal thyroid function in pediatric Obsessive Compulsive Disorder (OCD) versus controls, and to explore the relation between baseline thyroid measures and response to clomipramine treatment, and the effects of treatment on thyroid hormones. METHODS Sixteen children and adolescents with DSM-III-R OCE and 13 control children and adolescents without psychiatric illness w...

This work aims is to evaluate the therapeutic efficacy of cognitive behavior therapy (CBT) in pediatric patients with obsessive-compulsive disorder (OCD) who had not previously been treated with either pharmacotherapy or psychotherapy and who remained medication-free during CBT. Sixteen OCD outpatients, 8-17 years of age, were treated in a 12-week open trial with manualized CBT. Target symptoms...

Research on the relationship between personality factors and obsessive-compulsive disorder (OCD) has proved difficult to interpret due to conceptual problems including a lack of consensus on the model of personality employed as a framework as well as a failure to consider the clinical heterogeneity of the disorder. The aim of this study was to examine the dimensional personality profile associa...

OBJECTIVE To determine the safety and efficacy of fluvoxamine for the treatment of children and adolescents with obsessive-compulsive disorder (OCD) with a double-blind, placebo-controlled, multicenter study. METHOD Subjects, aged 8 to 17 years, meeting DSM-III-R criteria for OCD were recruited from July 1991 to August 1994. After a 7- to 14-day single-blind, placebo washout/screening period,...

abstract the purpose of present research was to determinate effectiveness of inference-based therapy on reduction of obsession and compulsion symptoms. thirty women who had received diagnosis of ocd by clinical interview (scid) were placed with randomization in experimental and control (wait list) groups. participants completed yale-brown obsessive compulsive scale(y-bocs) and inferential confu...