PURPOSE To test whether the triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me) and the rexinoid LG100268 (268) prevent the formation of estrogen receptor (ER)-negative mammary tumors or either arrest the growth or cause regression of established tumors in MMTV-neu mice. EXPERIMENTAL DESIGN For prevention, mice were fed control diet, CDDO-Me (60 mg/kg diet), ...

When observed by XMM–Newton in 2003, the type 1.5 quasi-stellar object 2MASS 0918+2117 was found to be in a low state, with an X-ray flux approximately four to five times fainter than during an earlier Chandra observation. The 2–6 keV spectrum was unusually hard (photon index ∼ 1.25), with evidence for a reflection-dominated continuum, while a soft excess visible below ∼1 keV prevented confirma...

To find out the presence of asymptomatic pulmonary hypertension by 2D ECHO who have metabolic syndrome WHO diagnostic criteria (presence insulin resistance plus any following two criteria, namely hypertension, hypertriglyceridemia, low HDL, BMI >30 mg/kgm2, urinary albumin: creatinine ratio > 30 mg/dl) and obstructive sleep apnoea done polysomnography. The secondary objective is to assess diabe...

BACKGROUND/AIM Infertility is defined as the inability to conceive after at least 1 year of unprotected intercourse. In about one third of infertile couples, a male factor is the primary problem. Thus, the present study aimed to determine the most common risk factors for male infertility in Iranian men. MATERIALS AND METHODS This case-control study included 268 men attending an infertility cl...

BACKGROUND We aimed to examine the association of appetitive motives with a non-exercise lifestyle, defined as exercising less than once per year, in a young adult population. MATERIAL AND METHODS We asked university students to answer questions about their exercise habits. We also assessed their appetitive motives, with or without hunger, by using a simple questionnaire in a preliminary surv...

We have recently identified by cDNA cloning a set of genes that are rapidly activated in mouse 3T3 cells by serum or purified growth factors. Here we report that the cDNA (clone 268) derived from one of these immediate early genes (zif/268) encodes a protein with three tandem "zinc finger" sequences typical of a class of eukaryotic transcription factors. The mRNA of zif/268 is present in many o...

OBJECTIVE Since January 2008, obese women with type 2 diabetes were advised to gain 0-5 kg during pregnancy. The aim with this study was to evaluate fetal growth and perinatal morbidity in relation to gestational weight gain in these women. RESEARCH DESIGN AND METHODS A retrospective cohort comprised the records of 58 singleton pregnancies in obese women (BMI ≥30 kg/m(2)) with type 2 diabetes...