The stability of polymeric nanoparticles in serum is critical to their use in drug delivery where dilution after intravenous injection often results in nanoparticle disassembly and drug unloading; however, few investigate this in biologically relevant media. To gain greater insight into nanoparticle stability in blood, the stability of self-assembled polymeric micelles of poly(d,l-lactide-co-2-...

Poly(ethylene glycol)-block-poly(aspartate-hydrazide) (PEG-p(Asp-Hyd)) was modified using either levulinic acid (LEV) or 4-acetyl benzoic acid (4AB) attached via hydrazone bonds. Paclitaxel (PTX) conjugated to the linkers formed PEG-p(Asp-Hyd-LEV-PTX) and PEG-p(Asp-Hyd-4AB-PTX). PEG-p(Asp-Hyd-LEV-PTX) and PEG-p(Asp-Hyd-4AB-PTX) assemble into unimodal polymeric micelles with diameters of 42 nm a...

Purpose: To establish small-sized superparamagnetic polymeric micelles for magnetic resonance and fluorescent dual-modal imaging, we investigated the feasibility of MR imaging (MRI) and macrophage-targeted in vitro. Methods: A new class of superparamagnetic iron oxide nanoparticles (SPIONs) and Nile red-co-loaded mPEG-Lys3-CA4-NR/SPION polymeric micelles was synthesized to label Raw264.7 cells....

The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are sorely needed for brain tumor therapy. Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain. Intranasal application of nano-sized micelles that have been modified with Tat peptide facilitates brain deli...

In relation to recent advances in nanobiotechnologies, cancer-targeted therapy using nano-scaled drug carriers (nanocarriers) has been attracting enormous attention with success in clinical studies. Polymeric micelles, core-shell-type nanoparticles formed through the self-assembly of block copolymers, are one of the most promising nanocarrier, because their critical features such as size, stabi...

Tri-block copolymers (poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide), represented as EOxPOyEOx), pluronics (F127 = EO106PO70EO106, P65 = EO20PO30EO20, P85 = EO27PO39EO27, P103 = EO17PO55EO17, and P123 = EO20PO70EO20) and cationic surfactants (cethyltrimethylammonium bromide (CTAB)), two surfactant systems, form complex micelles that self-assemble into mesostructured particles w...

multiple sclerosis (ms) is one of the most important autoimmune diseases recognized by demyelination and axonal lesion. it is the most common cause of disability in the young population. various immunomodulatory and immunosuppressive therapies, including different formulations of interferon beta (ifnβ), glatiramer acetate (ga), mitoxantrone, and natalizumab are available for this disease. howev...

Polymeric micelles, which are formed by the self-assembly of block copolymers, can load various substances and have received attention as drug carriers. Negatively charged nucleic acids such as DNA or RNA are some of the drugs delivered by polyion complex-based polymeric micelles (polyplex micelles). Polyplex micelles are expected to be nonviral gene carriers instead of viral vectors, which hav...