Multidrug-resistant and difficult-to-treat Acinetobacter baumannii may be responsible for nosocomial infections. The production of carbapenem-hydrolyzing class D β-lactamases (CHDLs) and extended-spectrum β-lactamase (ESBLs) of the GES type possessing a carbapenemase activity has been increasingly reported worldwide in A. baumannii. The aim of this study was to analyze the resistance mechanisms...

conclusions coexistence of the blaoxa-51, blaoxa-23 and blaoxa-24/40 like genes, along with formation of strong biofilm, in mdr-ab strains particularly with indiscriminate use of imipenem, complicated treatment of the patients infected with these bacteria in the hospitals understudy. background emergence and spread of carbapenemase (blaoxa) genes in multidrug resistant acinetobacter baumannii (...

conclusions this study was the first report of the emergence of the plasmid-encoded blaoxa genes among e. cloacae isolates in iran. these findings highlight the need to use appropriate infection control policy and rational antibiotic therapy to reduce further spread of these resistant bacteria in the studied hospitals. results in total, 48 esbl-producing isolates (58.5%) were positive for the b...

We report a 63,584-bp conjugative IncL plasmid (pUR17313-1) from an Enterobacter cloacae clinical isolate, containing a blaOXA-48 gene. The plasmid sequence also carried important mobile genetic elements involved in the spread of antibiotic resistance, namely, the Tn1999.2 composite transposon, which enclosed blaOXA-48-, integrase-, and transposase-encoding genes.

Objectives: To describe the genetic environment, transferability, and antibiotic susceptibility of one clinical Klebsiella pneumoniae isolate harboring both blaOXA-48 and blaNDM-1 on different plasmids from a Chinese hospital. Methods: The isolate was subjected to antimicrobial susceptibility testing and multilocus sequence typing using Etest and PCR. The plasmids harboring blaOXA-48 and blaNDM...

In this study, the performance of the "RESIST-3 O.K.N. K-SeT" (Coris BioConcept, Gembloux, Belgium) immunochromatographic assay was evaluated in 132 Klebsiella pneumoniae comprising 102 carbapenem resistant and 30 carbapenem susceptible isolates. Genotypically known isolates of Gram negative bacteria (n=22) including various species were also tested by the assay as controls. The isolates tested...

Background and Objectives Acinetobacter baumannii bacteremia are grave because of the multi-resistance of the organism to antibiotics. This study aimed to determine the prevalence of A. baumannii isolated from blood cultures and to describe their antibiotic resistance patterns. Materials and Methods A retrospective longitudinal study was conducted on blood cultures between 2010 and 2014 from ...

ObjectivesOur aim was to validate the INCREMENT-CPE score (ICS) in patients hospitalized intensive care unit (ICU) with bacteraemia due carbapenemase-producing Klebsiella pneumoniae (CP-Kp).MethodsThe study conducted ICU of University General Hospital Patras, Greece, during a 10-year period (2010–2019). Patients monomicrobial CP-Kp were included. Primary outcome 14-day mortality. MICs meropenem...

In recent years, different resistance genes have been found in Acinetobacter spp., especially in the species A. baumannii. We describe two isolates of carbapenem-resistant A. nosocomialis harboring ISAba1-blaOXA-23 and blaOXA-51 found in patients from the city of Porto Alegre, southern Brazil. To the best of the authors' knowledge, this is the first report of carbapenem-resistant A. nosocomiali...

Background: Urosepsis is one of the most common infections that require empirical broad spectrum antibiotics immediately after diagnosis. This has led to development bacterial resistance by acquiring capability destroy β-lactam ring. Methodology: a cross-sectional hospital-based study. The study was conducted from 2019 2020 at Gezira Hospital for Renal diseases and surgery (GHRDS). A hundred pa...