The ER-resident molecular chaperone BiP (binding protein) was overexpressed in soybean. When plants growing in soil were exposed to drought (by reducing or completely withholding watering) the wild-type lines showed a large decrease in leaf water potential and leaf wilting, but the leaves in the transgenic lines did not wilt and exhibited only a small decrease in water potential. During exposur...

Verification techniques have become popular in software and hardware development. They increase confidence and potentially provide rich feedback. However, with increasing complexity verification techniques are more likely to contain errors themselves. Many verification tools use invariants of the considered systems for their analysis. These invariants are often generated by the verification too...

The immunoglobulin (Ig) molecule is composed of two identical heavy chains and two identical light chains (H2L2). Transport of this heteromeric complex is dependent on the correct assembly of the component parts, which is controlled, in part, by the association of incompletely assembled Ig heavy chains with the endoplasmic reticulum (ER) chaperone, BiP. Although other heavy chain-constant domai...

BACKGROUND Patients with nonischemic left ventricular cardiomyopathy (LVCM) and ventricular tachycardia (Vt) have complex 3-dimensional substrate with variable involvement of the endocardium (ENDO) and epicardium (EPI). The purpose of this study was to determine whether ENDO unipolar (UNI) mapping with a larger electric field of view could identify EPI low bipolar (BIP) voltage regions in patie...

Reaction of 2,6-difluoropyridine with 2 equiv of indazole and NaH at room temperature affords a mixture of 2,6-bis(indazol-1-yl)pyridine (1-bip), 2-(indazol-1-yl)-6-(indazol-2-yl)pyridine (1,2-bip), and 2,6-bis(indazol-2-yl)pyridine (2-bip), which can be separated by solvent extraction. A two-step procedure using the same conditions also affords both 2-(indazol-1-yl)-6-(pyrazol-1-yl)pyridine (1...

Bounded Intention Planning (BIP) [7] is a pruning approach for optimal planning with unary operators. BIP has the flavor of partial order reduction, which has recently found increasing interest for optimal planning [4, 6]. However, although BIP is claimed to be a variant of stubborn sets [3] in the original paper, no proof is given for this claim. In this paper, we shed light on the relationshi...

Bleomycin-induced pneumonitis (BIP) is a serious and potentially fatal adverse effect of bleomycin. Currently, BIP is treated on an empirical basis with high dose steroid. Pirfenidone is a new antifibrotic drug, which has been proven beneficial in idiopathic pulmonary fibrosis and is able to inhibit or reverse BIP in animal models. Here, the first two cases of human BIP treated with pirfenidone...

Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com that frequently occur in cancer patients including pneumonia, lymphangitis carcinomatosa, and heart failure. Most predominant clinical symptoms and signs encompass a non-productive cough and exertional dyspnoe, gradually increasing in severity, while at physical examination bibasilar crep...

Verification of component-based systems still suffers from limitations such as state space explosion since a large number of different components may interact in an heterogeneous environment. Those limitations entail the need for complementary verification methods such as runtime verification based on dynamic analysis and prone to scalability. In this paper, we integrate runtime verification in...