We report a versatile approach for covalent surface-assembly of proteins onto selected electrode patterns of pre-fabricated devices. Our approach is based on electro-assembly of the aminopolysaccharide chitosan scaffold as a stable thin film onto patterned conductive surfaces of the device, which is followed by covalent assembly of the target protein onto the scaffold surface upon enzymatic act...

Osteoporosis (OP) is a serious disease and its early diagnosis is very important at the right time. These days, there are some conventional techniques of the diagnosis of this disease but these techniques have their limitations and reliable information is not obtained at the initial stage of the disease. Therefore, a new technique for the detection of OP at an early stage is required to be deve...

Microelectromechanical system (MEMS) development has become an active area for research in over the last decade. This area has advanced rapidly in recent years due to the potential ability of MEMS devices to perform complex functions in a smaller area. There is also the prospect to develop devices that can (1) be easily manufactured, (2) offer low power consumption, and (3) reduce waste. Especi...

29 THE 4TH ANNUAL IEEE INTERnational Conference on Nano/Microengineered Molecular Systems (IEEE-NEMS) was held at the Sheraton Dameisha Resort in Shenzhen, China, 5–8 January 2009. More than 300 papers were presented by leading micro/nanotechnology researchers in academia and industry from around the globe. Topical areas of the conference included microelectro mechanical systems (MEMS), BioMEMS...

Introduction to BioMEMS” by Albert Folch is a well written textbook for advanced undergraduate and introductory graduate level courses in biological applications of micro-electro-mechanical systems and lab-on-a-chip devices. It provides coverage of both historical perspectives and the latest developments in this rapidly developing field. The extensive use of color figures, the non-extensive use...

We present a method for sub-micron machining of flexible, thin-film structures fully encapsulated in biocompatible polymer poly(chloro-p-xylylene) (Parylene C) that improves feature size and resolution by an order of magnitude compared to prior work. A low temperature electron beam lithography (EBL) process compatible with Parylene-coated silicon substrates was developed, and characterized usin...

We present a method for submicron fabrication of flexible, thin-film structures fully encapsulated in biocompatible polymer poly (chloro-p-xylylene) (Parylene C) that improves feature size and resolution by an order of magnitude compared with prior work. We achieved critical dimensions as small as 250 nm by adapting electron beam lithography for use on vapor deposited Parylene-coated substrates...