Biomaterial-associated infection is one of the most common complications related to the implantation of any biomedical device. Several in vivo imaging platforms have emerged as powerful diagnostic tools to longitudinally monitor biomaterial-associated infections in small animal models. In this study, we directly compared two imaging approaches: bacteria engineered to produce luciferase to gener...

Biomaterial research has been going on for several years, and many companies are heavily investing in new product development. However, it is a contentious field of science. science that combines materials medicine. The replacement or restoration damaged tissues organs enhances the patient’s quality life. deciding aspect whether not body will accept biomaterial. A biomaterial used an implant mu...

For over 20 years, nanostructured porous silicon (nanoPS) has found a vast number of applications in the broad fields of photonics and optoelectronics, triggered by the discovery of its photoluminescent behavior in 1990. Besides, its biocompatibility, biodegradability, and bioresorbability make porous silicon (PSi) an appealing biomaterial. These properties are largely a consequence of its part...

This work presents the nanoindentation and XPS results of a newly-developed biomaterial of titanium TNZ alloy after different surface treatments. The investigations were performed on the samples AR (as received), EP (after a standard electropolishing) and MEP (after magnetoelectropolishing). The electropolishing processes, both EP and MEP, were conducted in the same proprietary electrolyte base...

The healthy heart comprises many different cell types that work together to preserve optimal function. However, in a diseased heart the function of one or more cell types is compromised which can lead to many adverse events, one of which is myocardial infarction (MI). Immediately after MI, the cardiac environment is characterized by excessive cardiomyocyte death and inflammatory signals leading...

In order to study how the geometric parameters and shape of the micro-structure surface of a bionic heart valve affects hemocompatibility, mastoid micro-structures with different periodic space were fabricated using a femtosecond laser on a polyurethane (PU) surface. The apparent contact angles of droplets on the micro-structure surfaces were measured to characterize their wettability. Then a s...

Biofilms on biomaterial implants are hard to eradicate with antibiotics due to the protection offered by the biofilm mode of growth, especially when caused by antibiotic-resistant strains. Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in various biomedical applications, such as targeted drug delivery and magnetic resonance imaging. Here, we evaluate the hypothesis that SPI...

OBJECTIVE To study the pathogenesis of aseptic loosening: in particular, to determine whether macrophages responding to particles of biomaterials commonly used in arthroplasty surgery for arthritis are capable of differentiating into osteoclastic bone resorbing cells, and the cellular and hormonal conditions required for this to occur. METHODS Biomaterial particles (polymethylmethacrylate, hi...

Grafting of the maxillary sinus is an established treatment modality to provide sufficient bone for the fixation of dental implants. We stated the hypothesis that the porous fluorohydroxyapatitic (FHA) biomaterial FRIOS Algipore could be used as a suitable biomaterial for sinus grafting in severely atrophic maxillae. To investigate the accuracy of our hypothesis, 69 trephine specimens from 26 p...

OBJECTIVES This study investigated the time-dependent remodeling and growth potential of porcine small intestine submucosa as a biomaterial for the reconstruction of pulmonary arteries in a lamb model. METHODS Left pulmonary arteries were partially replaced with small intestine submucosal biomaterial in 6 lambs. Two animals each were humanely killed at 1, 3, and 6 months. Computed tomographic...