Bacteriophage therapy is an important alternative to antibiotics in the current era of multidrug resistant pathogens. We reviewed the studies that dealt with the therapeutic use of phages from 1966-1996 and few latest ongoing phage therapy projects via internet. Phages were used topically, orally or systemically in Polish and Soviet studies. The success rate found in these studies was 80-95% wi...

der matologic consequences of chr omium exposure. The role of bioavailability figured prominently in both issues. Individuals whose homes or workplaces are on former chromium-waste dlumpsites an( lparticularly children who play on such sites are likely to have skin contact with chromium compoun(ls. If they ar e expose(l at all it would be to a relatively low (lose, but exposure is likely to be ...

Phytoextraction may be applied at field scale when the removal of bioavailable metals is the specific target of the technology. Residual metals in soil can be considered substantially inert or to be evaluated by site specific risk analysis.

OBJECTIVE To assess and compare the pharmacokinetics and bioavailability of methylergometrine (ME) in men and non-pregnant women. DESIGN A cross-over design was used for an oral dose of 0.125 mg and an intravenous dose of 0.200 mg of ME in 6 men and 6 non-pregnant women (parallel-design in gender). RESULTS After intravenous administration, the pharmacokinetic profile of ME was described wit...

In the text S.Piekarski, M.Rewekant, “On applications of conservation laws in pharmacokinetics”,(arXiv:1208.3847) it has been mentioned that some information on bioavailability and bioequivalence of drugs can be obtained from simulations based on the conservation laws. Here we shortly discuss that possibility starting from the fundamental pharmacokinetic parameter called AUC (Area Under the Cur...

The workshop was organised to discuss the validity and limitations of existing functional markers of Se status in human subjects and to identify future research priorities in this area. Studies presented as part of this workshop investigated: the bioavailability of Se from different dietary sources; potential functional markers of Se status; individual variation in response to Se; the effect of...

Vinpocetine is extensively metabolized in rats, dogs and humans, and the plasma clearance approximates the hepatic plasma flow in each of the species. In vitro degradation studies with hepatocytes have shown that the activity of human hepatocytes is about one order of magnitude higher than the activity of dog hepatocytes, and two orders of magnitude higher than that of rat hepatocytes. These di...