Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved by the US FDA for treatment of adults with moderate-to-severe plaque psoriasis who are candidates systemic therapy or phototherapy. Deucravacitinib was significantly more efficacious than placebo apremilast and well tolerated in previous reports from phase 3 POETYK PSO-1 trial. Here, we examin...

BACKGROUND Esthetics and the health of oral implants are based upon the soft tissue reaction and biologic width (BW). METHODS Twelve dental implants were placed in the maxilla and mandible of a patient who smoked. Permanent standard abutments and temporary restorations were immediately fixed in place during the surgery stage. The definitive restorations were placed 4 months after loading with...

In this paper we explore the boundary between biology and the study of formal systems (logic).

Marginal integrity is one of the main factors that contribute to outcome a restoration and longevity cast restorations. An increased significance on perio–restorative interface in restorative dentistry essential enable utilization concept biologic width practical manner. The goal, regarding management gingival tissues, ensure peridontium healthy state. oral cavity difficult treat because lips...

This study assessed the occurrence of indicators for suboptimal biologic therapy among ulcerative colitis (UC) and Crohn's disease (CD) patients over time in the United States (US). Data from a large US claims database (2005-2013) were used to retrospectively identify patients with diagnosed with either UC or CD who were new biologic users. Indicators of suboptimal biologic therapy included: do...