Whole-genome sequencing (WGS) is becoming available as a routine tool for clinical microbiology. If applied directly on clinical samples, this could further reduce diagnostic times and thereby improve control and treatment. A major bottleneck is the availability of fast and reliable bioinformatic tools. This study was conducted to evaluate the applicability of WGS directly on clinical samples a...

MOTIVATION Next-generation sequencing technologies have led to the widespread use of -omic applications. As a result, there is now a pronounced bioinformatic bottleneck. The general model organism database (GMOD) tool kit (http://gmod.org) has produced a number of resources aimed at addressing this issue. It lacks, however, a robust online solution that can deploy heterogeneous data and softwar...

Analysis of genetic population structure an endangered Serranid fish species in the South Korean waters: a bioinformatic simulationKhaled Mohammed-Geba

Cells and organisms are governed by networks of genetic, physical and metabolic interactions between proteins and other their substrates, such as DNA, RNA, and other biologically important molecules. Large scale experimental studies of interactions between components of biological systems have been performed for a variety of eukaryotic organisms. However, there is a dearth of such data for plan...

The grid is a promising tool to resolve the crucial issue of software and data integration in biology. In this paper, we have reported on our experience in the deployment of bioinformatic grid applications within the framework of the DataGrid project. These applications inquired the potential impact of grids for CPU demanding algorithms and bioinformatics web portals and for the update and dist...

Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory networks. MiRNAs are endogenous single-stranded non-coding RNAs (~22-nt long) that regulate gene expression at the post-transcriptional level. Through pairing with mRNA, miRNAs can down-regulate gene expression by inhibiting translation or stimulating mRNA degradation. In some cases they can also up-regulate the ...

Over the past 30 years, genomic and bioinformatic analysis of human adenoviruses has been achieved using a variety of DNA sequencing methods; initially with the use of restriction enzymes and more currently with the use of the GS FLX pyrosequencing technology. Following the conception of DNA sequencing in the 1970s, analysis of adenoviruses has evolved from 100 base pair mRNA fragments to entir...

Morusin, an active constituent of the mulberry plant (Morus alba), exhibits inhibitory effects on several types cancer cells in vitro, including breast cancer. This study aimed to identify potential target proteins morusin, investigate binding energy, and explore type interactions between morusin protein. Morusin was searched using PubMed, STITCH, STRING, Cytoscape databases. Subsequently, obta...