Biogenic amines (BAs) are known as toxic substances and formed in foods as a result of microbial action during fermentation and storage (Shalaby, 1996; Santos, 1996). BAs could cause diseases with food poisoning symptoms such as stimulating the nerves and blood vessels in man and animals (Joosten, 1988). The most important BAs found in foods are putrescine, cadaverine, β-phenylethylamine, tyram...

The relationship between the electrochemical proton gradient (delta mu-H+) and the electrochemical gradient for biogenic amines (delta mu-A) was investigated in isolated chromaffin ghosts free of endogenous components and gradients. The addition of ATP to a ghost suspension resulted in the generation of a large proton concentration gradient (delta pH), acidic inside (measured by [14C]-methylami...

Biogenic amines are important neuromodulators whose discovery laid the foundation of modern neuropharmacology. These compounds (which include norepinephrine, dopamine, serotonin, and histamine) are stored in secretory vesicles located in the cytoplasm, are released into the extracellular space by regulated exocytosis, then activate specific G protein-coupled receptors (GPCRs) located in preand ...

[formula: see text] Hexahydrodipyrrins 15 (X=H2) have been prepared by two routes: Pd(0)-initiated coupling/cyclization of triflates 11 and alkyne amines 12 and reduction of semicorrins 26 (X=O).

Serendipity has long been a welcome yet elusive phenomenon in the advancement of chemistry. We sought to exploit serendipity as a means of rapidly identifying unanticipated chemical transformations. By using a high-throughput, automated workflow and evaluating a large number of random reactions, we have discovered a photoredox-catalyzed C-H arylation reaction for the construction of benzylic am...

Numerous studies have been reported concerning the role of monoamine oxidase (MAO) in the metabolism of biogenic amines, especially in the central nervous system and in the heart. A large number of compounds that inhibit MAO have been described, and some of these have been used therapeutically. For this reason we considered that differences in concentration and localization of the enzyme might ...

An efficient copper-catalyzed method for N-arylation of amines has been developed with part-per-million catalyst loadings at room temperature under air. Reactions of substituted (E)-1-(2-halophenyl)alkanone oximes with aliphatic amines or aromatic amines provided the N-arylation products in good to excellent yields.

In this general method for measuring the concentrations of neurotransmitters in body fluids by "high performance" liquid chromatography (HPLC), the procedures for extracting different biogenic amines from body fluids vary, but the basic chromatographic conditions are the same for all. We use citric/formic acid buffer as the mobile phase, a C18 column, and an electrochemical detector. Specificit...

Background In this study the influence of active ingredients of certain drugs on the activity of human diamine oxidase (DAO; EC 1.4.3.22) was quantified. DAO is the main enzyme in catabolism of biogenic amines in the intestine. Ingestion of food containing high amounts of biogenic amines in case of reduced activity of DAO leads to an accumulation of histamine which causes symptoms of histamine ...