نتایج جستجو برای: bioconjugate

تعداد نتایج: 260  

Journal: :Molecules 2015
Ana Gil-Mesón Alejandro M Roncero Ignacio E Tobal Pilar Basabe David Díez Faustino Mollinedo Isidro S Marcos

A series of sesterterpenoid bioconjugates with phospholipids and polyunsaturated fatty acids (PUFAs) have been synthesized for biological activity testing as antiproliferative agents in several cancer cell lines. Different substitution analogues of the original lipidic ether edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) are obtained varying the sesterterpenoid in position 1...

2018
Edyta Cędrowska Marek Pruszynski Agnieszka Majkowska-Pilip Sylwia Męczyńska-Wielgosz Frank Bruchertseifer Alfred Morgenstern Aleksander Bilewicz

The 225Ac radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately, the major challenge for radioconjugates labelled with 225Ac is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-targeted tissues. In the present work, we propose ...

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Yi Liu Ming-Xi Zhang Zhi-Ling Zhang Hai-Yan Xie Zhi-Quan Tian Kwok-Yin Wong Dai-Wen Pang

Biomacromolecules/Nanomaterials bioconjugate complexes have many applications in the interdisciplinary research fields. Accessible and easy synthesis methods of these complexes are the key roles for these applications. High quality water-soluble surface-charged quantum dots (QDs) were successfully prepared via surface modification by amphiphilic surfactants. The positively charged QDs can inter...

2016
Saurabh Jain Luca Aresu Stefano Comazzi Jianguo Shi Erin Worrall John Clayton William Humphries Sandra Hemmington Paul Davis Euan Murray Asmare A. Limeneh Kathryn Ball Eva Ruckova Petr Muller Borek Vojtesek Robin Fahraeus David Argyle Ted R. Hupp Edgar Meinl

Monoclonal antibodies are leading agents for therapeutic treatment of human diseases, but are limited in use by the paucity of clinically relevant models for validation. Sporadic canine tumours mimic the features of some human equivalents. Developing canine immunotherapeutics can be an approach for modeling human disease responses. Rituximab is a pioneering agent used to treat human hematologic...

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