BACKGROUND Bone allografts carry a risk of infection, so terminal sterilization by gamma irradiation at 25kGy is recommended; but is deleterious to bone quality. Contemporary bone banking significantly reduces initial allograft bioburden, questioning the need to sterilize at 25kGy. METHODS We inoculated allograft bone with Staphylococcus epidermidis and Bacillus pumilus, then exposed them to ...

OBJECTIVE This large, level A, retrospective cohort study set out to compare healing outcomes in three large cohorts of wound patients managed universally for bioburden: standard of care group, who were prescribed systemic antibiotics on the basis of empiric and traditional culture-based methodologies; treatment group 1, who were prescribed an improved selection of systemic antibiotics based on...

Abstract The management of skin and soft-tissue infections represents a burden for healthcare systems worldwide, demanding additional scientific efforts. Despite combined advances in modern medicine from different disciplines, chronic non-healing topical wounds still represent an unresolved clinical challenge. Nanotechnology has contributed significantly to the development advanced therapeutic ...

•Dry Hydrogen Peroxide reduces environmental contamination in air and on surfaces.•No-touch disinfection technology is an effective adjunct to manual cleaning.•Dry shown be no-touch technology.•Hospital achieves continuous with Dry Peroxide. BackgroundStandard cleaning practices are often inadequate. Persistent the environment poses infection risk that may mitigated by systems. This study evalu...

OBJECTIVE Most reusable biopsy forceps and all of the currently available single-use biopsy forceps do not have a port that allows fluid flow down the inner tubular shaft of the device. Reusable biopsy forceps are widely used and reprocessed in healthcare facilities, and single-use biopsy forceps are reprocessed either in-house (eg, in Canada and Japan) or by third-party reprocessors (eg, in th...

BACKGROUND Polymicrobial communities colonize all wounds, and biofilms are hypothesized to be a key link to the chronic state and stalled healing. Molecular methods offer greater insight when studying microbial ecology in chronic wounds, as only a small fraction of wound bacteria are cultured by currently available methods and studies have shown little agreement between culture and molecular ba...