Many peptides that are released in vitro or in vivo from animal or plant proteins are bioactive and have regulatory functions in humans beyond normal and adequate nutrition. Different health effects have been attributed to food-derived peptides, including antimicrobial properties, blood pressure-lowering (ACE inhibitory) effects, cholesterol-lowering ability, antithrombotic and antioxidant acti...

Marine organisms represent a valuable source of new compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active substances in the field of the development of bioactive products. In this paper, the molecular diversity of different marine peptides is described as well as information about their biological pr...

Lysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA present in the lysosomal multienzyme complex to facilitate the correct lysosomal routing, stability and activation of with beta-galactosidase and alpha-neuraminidase. Beside CTSA has role in inactivation of bioactive peptides including bradykinin, substances P, ...

Food-protein derived bioactive peptides are short amino acid chains that are inactive within the sequence of the parent protein, but can be released through hydrolysis by proteolytic enzymes. Several physiological effects have been attributed to these peptides, such as blood pressure reduction, scavenging of oxidative compounds, induction of satiety and reduction of cholesterol. Due to their ab...

Marine biofunctional peptides are protein molecules that promote health by blocking certain harmful chemical pathways in the human body, such as the laying down of cholesterol in blood vessels. Marine bivalves are considered one such rich source of these peptides and bioactive compounds. These, bioactive peptides possess various biological activities such as antibacterial, antioxidant, anticoag...

Understanding the dynamic behavior of nanostructural systems is important during the development of controllable and tailor-made nanomaterials. This is particularly true for nanostructures that are intended for biological applications because biomolecules are usually highly dynamic and responsive to external stimuli. In this Article, we investigated the structural and conformational dynamics of...

BACKGROUND The digestive hydrolysis of dietary proteins leads to the release of peptides in the intestinal tract, where they may exert a variety of functions, but their characterization and quantification are difficult. OBJECTIVES We aimed to characterize and determine kinetics of the formation of peptides present in the jejunum of humans who ingested casein or whey proteins by using mass spe...

Bioactive food peptides are encrypted within the sequence of food proteins but can be released during food processing (by enzymatic hydrolysis or fermentation) or during gastrointestinal transit. Among bioactive food peptides, those with antihypertensive activity are receiving special attention due to the high prevalence of hypertension in the Western countries and its role in cardiovascular di...

Cancer is one of the main chronic degenerative diseases worldwide. In recent years, consumption of whole-grain cereals and their derivative food products has been associated with a reduced risk of various types of cancer. The main biomolecules in cereals include proteins, peptides, and amino acids, all of which are present in different quantities within the grain. Some of these peptides possess...