Motivated by work on bio-operations on DNA strings, we consider an outfixguided insertion operation that can be viewed as a generalization of the overlap assembly operation on strings studied previously. As the main result we construct a finite language L such that the outfix-guided insertion closure of L is non-regular. We consider also the closure properties of regular and (deterministic) con...

A novel CMOS bio-pixel array which integrates assay substrate and assay readout is demonstrated for multiplex and multireplicate detection of a triplicate of cytokines with single digit pg ml(-1) sensitivities. Uniquely designed large area bio-pixels enable individual assays to be dedicated to and addressed by single pixels. A capability to simultaneously measure a large number of targets is pr...

BACKGROUND Hyperhomocysteinemia has been associated with coronary atherosclerosis in many, but not all, prospective and retrospective studies. Some on these inconsistencies may be attributed to methodological variabilities. METHODS In the present study, three newly commercially available assays and one in-house HPLC assay for total homocysteine (tHcy) were utilized in 99 subjects with angiogr...

The present study is aimed to evaluate the antioxidant and hepatoprotective properties of selected methanolic fractions Polyalthia longifolia (Sonn.) Thwaite seeds in ethanol-induced oxidative stress rats. Initially, extract was fractionated using column chromatography. preliminary screening these identified two main bioactive (F3 F5), which were found have significant radical scavenging metal ...

2010 platform (Roche Diagnostics). Ionized calcium and 25-hydroxyvita-min D (Nichols Advantage) were also measured in all samples. Results for the healthy individuals are presented in Fig. 1. The bio-intact PTH values measured by the IRMA and chemiluminescence immunoas-say were, on average, 50% and 30% lower, respectively, than the PTH measured by the Elecsys. Regression analysis demonstrated s...

Crude extracts of the aerial parts of Marrubium vulgare show a potent in vitro inhibition of KCl-induced contraction of rat aorta. Bio-guided fractionations, spectroscopic analysis and chemical derivatization revealed the furanic labdane diterpenes marrubenol and marrubiin as the most active compounds.

OBJECTIVES We have evaluated the recently Conformité Européenne (CE)-marked Bio-Rad Geenius human immunodeficiency virus (HIV)1/2 as a rapid and simple alternative to western blot for confirmation of HIV screening results. METHODS A total of 160 serum samples were tested: 44 HIV-1 reactive samples by a fourth-generation Murex HIV Ag/Ab and/or Vidas HIV Duo Ultra, five HIV-2 reactive samples, ...

B. Qiu, F. Gao, T. K. Foo, P. Karmarkar, E. Atalar, and X. Yang Radiology, Image-guided bio-molecular intervention section, University of Washington Medical Center, Seattle, WA, United States, Radiology, Johns Hopkins University, Baltimore, MD, United States, Applied Science Laboratory, GE Healthcare, Baltimore, MD, United States, Electrical and Electronics Engineering, Bilkent University, Anka...

Crystallographic insight-guided nanoarchitectonics of peptide-conjugated naphthalene diimide (NDI) is described. In a bio-inspired approach, non-proteinogenic α-amino isobutyric acid (Aib)- and alanine (Ala)-derived peptides orchestrated the 1D achiral and 2D chiral molecular ordering of NDI, respectively, which resulted in modulation of nanoscale morphology, chiroptical and conductivity proper...