Administration of the anticonvulsant 5,5-diphenylhydantoin sodium (DPH, Dilantin) depresses the level of serum protein-bound iodine (PBI) without inducing clinical hypothyroidism or changing other measures of thyroid function, such as 24-hour thyroidal accumulation of I131, thyroidal clearance of I131, serum cholesterol, and basal metabolic rate (1). Since DPH also induces a fall in the serum P...

We compared the clinical value of "Amerlex" (Amersham International) and "Pre-release Coat-A-Count" (Diagnostic Products Corp.) radioimmunoassay kits for free triiodothyronine with that of triiodothyronine, triiodothyronine/thyroxin-binding globulin ratio, and free triiodothyronine index in patients with thyroid disease, pregnant women, oral contraceptive users, thyroxin-binding globulin-defici...

We undertook a prospective longitudinal study of thyroid function in 36 pregnant women. There were significant increases in thyroxin-binding globulin, thyrotropin, and triiodothyronine. Albumin, free thyroxin (measured by an analog and a nonanalog method), and the free thyroxin index were significantly decreased. Results for the free thyroxin methods were correlated with each other in each trim...

A corticosteroid-binding protein was detected in the whey of human colostrum and milk which resembles serum corticosteroid-binding globulin in certain respects: the equilibrium association constants for cortisol and progesterone binding and the apparent molecular size, as determined by Sephadex G-200 chromatography, were similar, and cortisol andd progesterone competed strongly for binding to t...

We describe a simple method for evaluating thyroxine-binding globulin capacity and concentration from a single 1-cm blood spot on filter-paper used in a screening program for neonatal hypothyroidism. This method permits prompt diagnosis of about 90% of the infants with thyroxine-binding globulin deficiency in our abnormal low-thyroxine, low-thyrotropin population. There was excellent equivalenc...