Many tyrosine kinase-driven cancers, including chronic myeloid leukemia (CML), are characterized by high response rates to specific tyrosine kinase inhibitors (TKIs) like imatinib. In East Asians, primary imatinib resistance is caused by a deletion polymorphism in Intron 2 of the BIM gene, whose product is required for TKI-induced apoptosis. The deletion biases BIM splicing from exon 4 to exon ...

OBJECTIVE Ischemia hypoxia induces cardiomyocyte (CM) apoptosis in the process of acute myocardial infarction (AMI). It was showed that pro-apoptosis factor BIM participates in regulating tumor cell apoptosis under ischemia or hypoxia condition, while its role in CM apoptosis after AMI is still unclear. It was revealed that miR-24 expression was significantly reduced in myocardial tissue after ...

The current economic difficulties have affected most practitioners within the industry and, as a result, many firms and contractors are bidding for fewer projects, resulting in below-cost tenders. It is clear that, many firms and contractors are now operating on thin margins; which makes it increasingly difficult for them to commit to the introduction of new software applications and system upg...

We examined the role of the antiapoptotic molecule Bcl-2 in combating the proapoptotic molecule Bim in control of naive and memory T cell homeostasis using Bcl-2(-/-) mice that were additionally deficient in one or both alleles of Bim. Naive T cells were significantly decreased in Bim(+/-)Bcl-2(-/-) mice, but were largely restored in Bim(-/-)Bcl-2(-/-) mice. Similarly, a synthetic Bcl-2 inhibit...

a r t i c l e i n f o Building Information Modeling (BIM) has emerged as one of the key streams in construction and civil engineering research within the last decade. Given this interest in BIM and the rapidly increasing volume of BIM literature, it is important to understand and discern the core themes and trends emerging in BIM research, and its implications for broader research. The previous...

In this paper, the implementation of Building Information Modelling (BIM) systems in various selected countries is reviewed to highlight the successful practices in this field. In several situations, BIM was implemented in conjunction with Industry Foundation Classes (IFC) for better integration and interoperability of various components of BIM system. The roles of the public and private sector...

a r t i c l e i n f o Keywords: BIM Collaborative design Integrated design system Data exchange IFC For effective collaboration among construction project participants, the use of Building Information Model (BIM) has become more common throughout the building life cycle. However, due to the use of different BIM-based software among collaborators during the design, a variety of problems have occ...

A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of marinopyrroles to Mcl-1. Benzyl- and benzyl methoxy-containing sulfide deriva...

This paper presents an endeavour of integration of GIS (Geographical Information System) and BIM (Building Information Modelling) for indoor geovisual analytics. The merits of two types of technologies, GIS and BIM are firstly analysed in the context of indoor environment. GIS has well-developed capabilities of spatial analysis such as network analysis, while BIM has the advantages for indoor 3...

Programmed cell death (apoptosis) is an important host defense mechanism against intracellular pathogens, such as viruses. Accordingly, viruses have evolved multiple mechanisms to modulate apoptosis to enhance replication. Varicella-zoster virus (VZV) induces apoptosis in human fibroblasts and melanoma cells. We found that VZV triggered the phosphorylation of the proapoptotic proteins Bim and B...