Background: Considering the increasing rates of early hospital discharge and kernicterus in healthy full term newborns, timely identification of neonates at risk of severe hyperbilirubinemia is of great significance. The aim of this study was to investigate the predictive value of umbilical cord serum (UCS) bilirubin level for subsequent hyperbilirubinemia. Moreover, we compared the predictive ...

Bilirubin has both antioxidant activity and cardio-protective potential. Decreased levels are associated with predicting CAD. Recent studies showed that bilirubin has inverse correlation with glycemic status. So in this we evaluated the role of Hepato-biliary function as a marker of predictor CAD in patient with T2DM. Total 100 subjects included 50 T2DM patients with CAD and 50 T2DM without CAD...

The present work examines the protective mechanisms of methanol extract of Oldenlandia umbellata (MEOU) in carbon tetrachloride intoxicated rats. Rats were treated with carbon tetrachloride at the dose of 1 ml/kg body weight intraperitonially once in every 72 hrs for 16 days. The hepatoprotective activity of methanol extract of Oldenlandia umbellata was evaluated by measuring levels of serum ma...

Background: Regarding the diagnostic errors of the classic criteria including serum ascites albumin gradient (SAAG), total protein concentration and the adapted Light et al’s criteria in distinguishing transudate versus exudates, we evaluated the ascitic fluid to serum bilirubin ratio as a new criteria in this regard. We also evaluated whether the combination of bilirubin ratio with each of the...

Septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. The severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. The direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as O 2 - , p...

Bilirubin, the end-product of heme catabolism, circulates in non-pathological plasma mostly as a protein-bound species. When bilirubin concentration builds up, the free fraction of the molecule increases. Unbound bilirubin then diffuses across blood-brain interfaces (BBIs) into the brain, where it accumulates and exerts neurotoxic effects. In this classical view of bilirubin neurotoxicity, BBIs...

Serum levels of glucose, bilirubin, calcium, phosphorus, protein and albumin were measured in a group of nine healthy men before, and on the first, 10th, 20th and 29th day of Rarnadan, and four weeks after Islamic fasting was terminated. There was a significant reduction in body weight, a significant increase in serum bilirubin and a slight decrease in calcium during Ramadan. Serum glucose decr...

Induction of hyperbilirubinemia in experimental rabbits by phenylhydrazine was optimized in terms of dose, dose interval and number of doses using response surface methodology. Central Composite Design was employed using five levels for each of the three input variables. Degree of hyperbilirubinemia was measured in terms of bilirubin level in serum of animals. A dose dependent significant eleva...