Sundaram, U., S. Wisel, S. Stengelin, W. Kramer, and V. Rajendran. Mechanism of inhibition of Na1-bile acid cotransport during chronic ileal inflammation in rabbits. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1259– G1265, 1998.—In the chronically inflamed ileum, unique mechanisms of alteration of similar transport processes suggest regulation by different immune-inflammatory mediat...

AIM To determine associations between enterogastric bile reflux and gastric mucosal pathology. METHOD A retrospective study using fasting gastric juice bile acid measurements and antral or prestomal biopsy specimens from 350 patients, 66 of whom had previously undergone surgery that either bypassed or disrupted the pyloric sphincter. RESULTS Bile reflux was positively associated with reacti...

Abstract Background Retroperitoneal biloma is a rare complication of gallstone disease. Only handful cases have been reported in the literature with various mechanisms postulated. Here, we report case spontaneous retroperitoneal arising from gallbladder perforation. Methods An 87-year-old female patient presented right upper quadrant pain context known Inflammatory markers and liver function te...

spillage of scoleces is a major problem in surgery of hydatid cysts, because each of them may develop into a new cyst if it settles on a suitable site such as the peritoneum. many surgeons believe that scoleces in ruptured hydatid cysts of the liver containing bile are not able to develop new cysts, because bile kills thein. in order to prove this idea, the viability of scoleces in such cysts w...

Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Object...

Although inflammation is known to impose changes in the expression and activity of drug transporters, little is known about the impact of inflammatory stimuli on these transporters during pregnancy. Our objective was to study the effect of viral-induced inflammation on key maternal hepatic and placental drug transporters and their endogenous substrates. Acute inflammation was induced in pregnan...

Bile acid accumulation in liver with cholangiolar neoplastic lesions may occur before cholestasis is clinically detected. Whether this favors intrahepatic cholangiocarcinoma development has been investigated in this study. The E. coli RecA gene promoter was cloned upstream from Luc2 to detect in vitro direct genotoxic ability by activation of SOS genes. This assay demonstrated that bile acids w...

UNLABELLED Bile acid accumulation in liver with cholangiolar neoplastic lesions may occur before cholestasis is clinically detected. Whether this favors intrahepatic cholangiocarcinoma development has been investigated in this study. The E. coli RecA gene promoter was cloned upstream from Luc2 to detect in vitro direct genotoxic ability by activation of SOS genes. This assay demonstrated that b...

Abstract Introduction This study explored near-infrared fluorescent cholangiography (NIRFC) with Indocyanine Green (ICG) during laparoscopic cholecystectomy (LC) surgery in a tertiary referral hepatobiliary unit. ICG binds to albumin and is excreted bile. NIRFC utilises the excretory properties of provide dynamic extrahepatic bile duct mapping LC. Method Non-randomised single centre feasibility...

Fasciola hepatica infestation is known to cause bile duct inflammation and biliary obstruction. Endoscopic retrograde cholangiopancreatography shows distinct features in some patients with fascioliasis, but the condition may be overlooked in chronic cases. The endoscopic retrograde cholangiopancreatograpy images must be carefully examined to rule out other possible causes of irregularity and th...