نتایج جستجو برای: biginelli like reaction

تعداد نتایج: 1041717  

Divya Verma Shubha Jain Srinivasa Rao Jetti,

Decatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a green heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from one-pot three-component cyclocondensation reaction of a β-ketoester, an aldehyde and urea/thiourea under solvent-free conditions is reported. This method provides an efficient and much improved modification of the original Biginelli reaction...

Journal: :Heterocyclic Communications 2022

Abstract In this study, we evaluated the performance of nano-?-Fe 2 O 3 –SO H catalyst in Biginelli reaction and synthesized 3,4-dihydropyrimidine-2-(1 )-ones. This was carried out under solvent-free ultrasonic irradiation conditions belonged to one-pot multicomponent reactions (MCRs) with an adopted aromatic aldehyde, ethyl acetoacetate, urea as starting materials for beginning reaction. The w...

2012
M. Mansouri A. Movahedian M. Rostami A. Fassihi

Biginelli-type pyrimidines contain an interesting moiety which has attracted considerable attention of medicinal chemists in the last few decades. Despite the very diverse pharmacologic effects ascribed to this kind of pyrimidines, there are few reports on the antioxidant evaluation of Biginelli pyrimidines. In this study synthesis of some novel Biginelli-type pyrimidines is reported. The prepa...

Aigin Bashti, Bahador Karami Saeed Khodabakhshi,

Molybdate sulfuric acid (MSA) has been prepared and used as catalyst for the Biginelli synthesis of some quinazolinones/thiones under solvent-free conditions. The catalyst loading is low and it shows recyclability. This method has advantages such as avoidance of the organic solvents, high yield of pure products, short reaction times and operational simplicity.

2008
Andreas Decken Matthew T. Zamora Dominique R. Duguay Christopher M. Vogels Stephen A. Westcott

A new Biginelli compound, C(18)H(25)BN(2)O(4)S(2), containing a boronate ester group was synthesized from a lithium bromide-catalysed reaction. The compound crystallizes with two independent mol-ecules in the asymmetric unit that differ mainly in the conformation of the ester functionality. The crystal structure is stabilized by inter-molecular N-H⋯O and N-H⋯S hydrogen bonds involving the 3,4-d...

2013
Trevor A Hamlin Nicholas E Leadbeater

An apparatus is reported for real-time Raman monitoring of reactions performed using continuous-flow processing. Its capability is assessed by studying four reactions, all involving formation of products bearing α,β-unsaturated carbonyl moieties; synthesis of 3-acetylcoumarin, Knoevenagel and Claisen-Schmidt condensations, and a Biginelli reaction. In each case it is possible to monitor the rea...

   This procedure has developed the use of TiO2 nanoparticles as an environmentally friendly and highly efficient heterogenous nanocatalyst for the eco-safe, facile and one-pot three-component Biginelli synthesis of biologically active corresponding 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives under solvent-free conditions. This eco-friendly protocol provi...

Ali Oudi Maryam Fatahpour Nourallah Hazeri,

In this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones havebeen developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective,inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isola...

Journal: :Molecules 2017
Naceur Hamdi Rawdha Medyouni Hallouma Bilel Lamjed Mansour Antonio Romerosa

In this study, novel phthalonitrile 3 and their corresponding metal-free 4 and metallophthalocyanine derivatives 5-7 bearing 2-isopropenyl-4-methoxy-1-methylbenzene groups were synthesized and characterized. 3,4-Dihydropyrimidinones have been synthesized by a modified Biginelli-type reaction with various metallophthalocyanines 5-7 as catalysts. Compared to the classical Biginielli reaction, the...

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