نتایج جستجو برای: beta neurotoxin
تعداد نتایج: 191444 فیلتر نتایج به سال:
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins ...
Botulinum neurotoxin (BoNT) is one of the most toxic substances known to produce severe neuromuscular paralysis. The currently used vaccine is prepared mainly from biohazardous toxins. Thus, we studied an alternative method and demonstrated that DNA immunization provided sufficient protection against botulism in a murine model. A plasmid of pBoNT/A-Hc, which encodes the fragment C gene of type ...
Animal models for Parkinson's disease (PD) are essential for understanding its pathogenesis and for development and testing of new therapies. Discoveries of endogenous neurogenesis in the adult mammalian brain give new insight into the cell-based approach for treatment of neurodegenerative disorders, such as PD. Although a great deal of interest has been focused on endogenous neurogenesis in ne...
introduction: submucoperichondrial injection of botulinum neurotoxin a (bta) in the nasal septum is a promising therapeutic option in the treatment of persistent allergic rhinitis (ar) and non-allergic rhinitis, and is safer and more effective than intraturbinate injection in reducing clinical symptoms. materials and methods: forty patients diagnosed with persistent ar or non-allergic rhiniti...
Endogenous nucleotides with extracellular functions may be involved in the complex neural control of human urinary bladder (HUB). Using HPLC techniques with fluorescence detection, we observed that in addition to ATP and its metabolites ADP, AMP and adenosine, electrical field stimulation (EFS; 4-16 Hz, 0.1 ms, 15 V, 60 s) of HUB detrusor smooth muscle coreleases novel nucleotide factors, which...
The present study investigated the ability of a number of presynaptic snake neurotoxins (snake beta-neurotoxins) to produce nerve-evoked train-of-four fade, tetanic fade and endplate potential run-down during the development of neuromuscular blockade in the isolated mouse phrenic-hemidiaphragm nerve-muscle preparation. All the snake beta-neurotoxins tested, with the exception of notexin, produc...
امروزه شهرها به عنوان یک سامانه، نیازمند مدیریت می باشند که به تعیین اهداف و برنامه پرداخته و فعالیت عناصر مختلف شهری را هماهنگ نماید. از این رو هدف اصلی در این پژوهش تعیین وضعیت مدیریت شهری در ساماندهی خدمات شهری منطقه 5 شهر کرمانشاه می باشد. روش پژوهش توصیفی- تحلیلی است و نحوه جمع آوری اطلاعات به صورت پیمایشی و استفاده از پرسشنامه محقق ساخته بوده که براساس فرمول کوکران حجم نمونه 320 نفر محاسب...
Botulism is a potentially lethal paralytic disease caused by botulinum neurotoxin. Human pathogenic neurotoxins of types A, B, E, and F are produced by a diverse group of anaerobic spore-forming bacteria, including Clostridium botulinum groups I and II, Clostridium butyricum, and Clostridium baratii. The routine laboratory diagnostics of botulism is based on the detection of botulinum neurotoxi...
Introduction and purpose: Masticatory muscles hyperactivity is currently a very common problem among adult population. The ignorance of the symptoms lack or unsuccessful treatment may lead to serious health complications, which major focus on improvement standard therapy for bruxism. aim study was provide broad review promising bruxism with botulinum neurotoxin injections. Material method: cond...
A monoclonal antibody (BA11) has been produced against Clostridium botulinum type A neurotoxin by the fusion of myeloma cells (P3 NS1/1-Ag4-1) with spleen cells from BALB/c mice immunized with botulinum type A neurotoxoid. The antibody bound specifically to botulinum type A neurotoxin, showing no cross-reactivity with types B and E botulinum toxins or with any of several other bacterial toxins ...
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