Background Beta cell dysfunction and death are critical steps in the development of both type 1 2 diabetes (T1D T2D), but underlying mechanisms incompletely understood. Activation essential tumor suppressor transcription factor P53 was linked to beta vitro has been reported several mouse models cells humans with T2D. Therefore, we investigated specific role dysfunction, vivo.

C-peptide, a key biomarker for beta-cell function in diabetes, has potential understanding and managing the disease, though its application type 2 diabetes is limited by insufficient evidence. It provides insights into endogenous insulin secretion faces challenges measurement standardization. In 1 C-peptide levels reflect beta cell loss, while higher indicate risk of progression. Preserved diff...

To explore the function of curcumin on cartilage cells, cell proliferation and apoptosis by transforming growth factor-beta/suppressor mothers against decapentaplegic/a disintegrin metalloproteinase with thrombospondin motifs-7 axis was objective study. The viability detected counting kit-8. expression factor-beta, suppressor decapentaplegic protein, a motifs-7, caspase-9, B-cell lymphoma 2, Bc...

Background: Although several studies have been done on quality of life of patients with Sickle Cell Disease (SCD), there is little research on the correlation of health-related quality of life (HRQoL) with self-efficacy in these patients. We aimed to determine the association between HRQoL and self-efficacy in patients with SCD and to explore the role of self-efficacy and demographic-clinical v...

The human amniotic membrane known as the innermost single epithelial-covered layer provides many applications such as applicable anti-inflammatory and anti-cancer effects. These immunomodulatory effects belongs to the epithelial cells, a type of epiblast-derived fetal stem cells which currently used for regenerative medicine and transplantation. These cells are collected by author-prepared faci...

Background: Sustainable and commercial production of secondary metabolites is a critical issue when dealing with its clinical application. Efforts are still being made to look for biotic or abiotic elicitors with more efficient and universal effects on the improvement of secondary metabolites. Objective: In order to evaluate the suitability of different biotic elicitors on P. harmala L. cell...

Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic r...