background and objective: alzheimer’s disease (ad) is a multifactorial disease with debilitating consequences and few therapeutic strategies exist for it. with regard to antioxidant capacity and anti-β-amyloid polymerization potential of ellagic acid, this study was conducted to evaluate the effect of this substance on enhanced acetylcholinesterase reactivity in an experimental model of alzheim...

Vascular remodeling is an important complication of hypertension with oxidative stress-related profibrotic pathways involved. The transforming growth factor β1 (TGF-β1) has been shown to be a potential target of vasoprotection, and has multiple roles in vascular remodeling. Acetyl-11-Keto-β-Boswellic Acid (AKBA) is one of the active principles of Boswellic acids, and shows antioxidant activity ...

Activation of signal transducers and activators of transcription-3 (STAT-3) has been linked with survival, proliferation, chemoresistance, and angiogenesis of tumor cells, including human multiple myeloma (MM). Thus, agents that can suppress STAT3 activation have potential as cancer therapeutics. In our search for such agents, we identified acetyl-11-keto-beta-boswellic acid (AKBA), originally ...

ABSTRACT Objective: To evaluate the effectiveness of complementary therapies in management symptom clusters children and adolescents with cancer undergoing palliative care. Method: Systematic review guided by Preferred Reporting Items for Reviews Meta-Analyses, resorting to databases MEDLINE, Web Science, Central Cochrane, PsycINFO. The identification, selection, inclusion, extraction, methodol...

Intervention in Obesity & Diabetes 11-Keto-β-Boswellic Acid and 5-Chloro-8-Hydroxyquinoline Attenuate Renal Damage Streptozotocin-Induced Diabetic Mice Ghulam Abbas1,2*, Sulaiman Al-Hashmi2*, Ahmed Al-Harrasi2*, René Csuk3, Issa Al-Amri1,4, Najeeb Ur Rehman2, Al-Adawi1 Samera Khalaf4 1Department of Biological Sciences Chemistry, University Nizwa, Sultanate Oman, Oman 2Natural Medical Research C...

Fig. 6 Effects of BA upon hepatic inflammation, determined by H&E stain, in mice with BA at 0, 0.05 or 0.1% for 4 weeks, and followed by APAP treatment. Normal groups had neither BA nor APAP treatments. BA groups had 0.1% BA intake without APAP treatment. Ishak inflammation score was used to quantify the injury area. Values are mean ± SD, n = 10. A representative image is shown for each group. ...